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227R-2

BCL6 (EP278) Rabbit Monoclonal Primary Antibody

Name: BCL6 (EP278) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP278, monoclonal

Application:

IHC (p)

Citations:

Technical Service

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Properties

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP278, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (227R-27), bottle of 7.0 mL predilute (227R-28), vial of 0.1 mL concentrate (227R-24), vial of 0.5 mL concentrate (227R-25), vial of 1.0 mL concentrate (227R-26), vial of 0.1 mL concentrate Research Use Only (227R-24-RUO), vial of 1.0 mL concentrate Research Use Only (227R-26-RUO), vial of 1.0 mL pre-dilute Research Use Only (227R-27-RUO), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (227R-28-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... BCL6(604)

Description

General description

BCL6 is a transcriptional regulator gene which codes for a 706-amino-acid nuclear zinc finger protein.¹ In normal tissue these antibodies have strong nuclear staining for a subset of B-lymphocytes, mostly located in germinal centers (GC).² BCL6 antibodies stain malignant cells in follicular lymphoma,³ diffuse large B-cell lymphomas,⁴ Burkitt lymphoma,⁴ classical Hodgkin lymphoma,⁵ as well as majority of tumor cells in nodular lymphocyte predominant Hodgkin lymphoma.⁶ BCL6 expression has been also seen in anaplastic large cell lymphomas (ALCL).⁷

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

RUO

Other Notes

BCL6 Positive Control Slides, Product No. 227S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000521752

0000501477

0000462155

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Expression of BCL-6 protein and CD138/syndecan-1 as B-cell markers in Hodgkin's disease.

A Carbone et al.

The International journal of biological markers, 14(3), 144-148 (1999-11-24)

B-cell differentiation immunophenotypes in classical Hodgkin lymphomas.

Maria Bai et al.

Leukemia & lymphoma, 47(3), 495-501 (2006-01-07)

The bcl6/CD10/MUM1/CD138 B-cell differentiation immunophenotypes were analysed in 101 cases of classical Hodgkin lymphomas (cHL) aiming to elucidate their histogenesis. Three major bcl6/CD10/MUM1/CD138 immunophenotypes were distinguished on the basis of the immunohistochemical positivity of Hodgkin and Reed-Sternberg (H/RS) cells: (a)

B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology.

Antonino Carbone et al.

Human pathology, 41(5), 621-631 (2010-04-20)

Published in September 2008, the updated World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues introduces provisional borderline categories for lymphoma cases that demonstrate overlapping clinical, morphological, and/or immunophenotypic features between well-established entities. These overlapping features pose real

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Global Trade Item Number

SKU	GTIN
227R-24-RUO	04061838781116
227R-27-RUO	04061836593940
227R-24	0841683128434
227R-26-RUO	04061836603380
227R-26	0841683128458
227R-28-RUO	04061836593957
227R-25	0841683128441
227R-27	0841683128465
227R-25-RUO	04061836603373
227R-28	0841683128472