261M-9
Glypican-3 (1G12) Mouse Monoclonal Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
1G12, monoclonal
Application:
IHC (p)
Citations:
7
biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
1G12, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (261M-94), vial of 0.5 mL concentrate (261M-95), bottle of 1.0 mL predilute (261M-97), vial of 1.0 mL concentrate (261M-96), bottle of 7.0 mL predilute (261M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG1
control
hepatocellular carcinoma (HCC)
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... GPC3(2719)
General description
Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation. GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC. Aditionally, this marker is expressed in many yolk sac tumors.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Glypican-3 Positive Control Slides, Product No. 261S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Regulatory Information
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Debra L Zynger et al.
The American journal of surgical pathology, 30(12), 1570-1575 (2006-11-24)
Glypican 3 (GPC3), a membrane-bound heparin sulfate proteoglycan, may play a role in promoting embryonic cell growth and differentiation. GPC3 is mutated in Simpson-Golabi-Behmel syndrome, characterized by tissue overgrowth and an increased risk of embryonal malignancies. Recently, GPC3 was reported
Wanda M P Coston et al.
The American journal of surgical pathology, 32(3), 433-444 (2008-02-28)
Distinguishing a well-differentiated hepatocellular carcinoma (HCC) from normal and cirrhotic liver tissue or benign liver nodules, such as hepatic adenoma (HA) and focal nodular hyperplasia (FNH), may be very difficult in some cases, particularly in small needle core biopsies. We
Dina Kandil et al.
Cancer, 111(5), 316-322 (2007-09-01)
Glypican-3 (GPC3) is a heparan sulfate proteoglycan which is elevated in the serum of patients with hepatocellular carcinoma (HCC), but not in healthy blood donors, or patients with benign liver disease. GPC3 immunohistochemistry (IHC) is a promising marker of HCC
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 261M-96-RUO | 04061836529796 |
| 261M-98 | 0841683131373 |
| 261M-96 | 0841683131359 |
| 261M-95 | 0841683131342 |
| 261M-97 | 0841683131366 |
| 261M-94 | 0841683131335 |