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272M-1

INI-1 (MRQ-27) Mouse Monoclonal Antibody

Name: INI-1 (MRQ-27) Mouse Monoclonal Antibody
Brand: SIGMA

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

MRQ-27, monoclonal

Application:

IHC (p)

Citations:

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biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-27, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (272M-14), vial of 0.5 mL concentrate (272M-15), bottle of 1.0 mL predilute (272M-17), vial of 1.0 mL concentrate (272M-16), bottle of 7.0 mL predilute (272M-18)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

control

brain, endothelial cells

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SMARCB1(6598)

Related Categories

Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

General description

INI-1, also known as SMARCB1, is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex. It is involved in chromatin remodeling and transcriptional regulation and functions as a tumor suppressor. Nuclear INI-1 expression is seen in virtually all normal human tissues and most malignancies but the INI-1 gene is often mutated or deleted in malignant rhabdoid tumors (MRT), including those arising in the central nervous system, leading to a lack of INI-1 expression.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

INI-1 Positive Control Slides, Product No. 272S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000491195

0000455182

0000450669

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Primary thoracic myxoid variant of extrarenal rhabdoid tumor in childhood.

D J Fowler et al.

Fetal and pediatric pathology, 25(3), 159-168 (2006-10-25)

Primary extrarenal rhabdoid tumors (RT) are now recognized as a specific entity in pediatric oncological pathology practice. We present an unusual case of a small cell myxoid variant of a thoracic RT in an infant and highlight the importance of

hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities.

F Bourdeaut et al.

The Journal of pathology, 211(3), 323-330 (2006-12-08)

Rhabdoid tumours (RTs) are rare but highly aggressive tumours of childhood. Their rarity and their miscellaneous locations make the diagnosis particularly challenging for pathologists. Central nervous system and peripheral RTs have been associated with biallelic inactivation of the hSNF5/INI1/SMARCB1 (hSNF5/INI1)

Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype.

Christine Haberler et al.

The American journal of surgical pathology, 30(11), 1462-1468 (2006-10-26)

Immunohistochemical lack of nuclear INI1 protein expression has been recently described as characteristic finding in atypical teratoid/rhabdoid tumors (AT/RTs), and has been suggested as useful marker to distinguish AT/RTs from other malignant pediatric central nervous system (CNS) tumors. In this

Multiple synchronous primary malignant neoplasms: A case report and literature review.

Linlin Hao et al.

Oncology letters, 26(4), 428-428 (2023-09-04)

Multiple primary malignant neoplasms (MPMN) are defined as two or more primary malignancies diagnosed in an individual. There is no association between these cancers, which can be classified into synchronous and heterochronous cancers depending on the time of diagnosis. The

Global Trade Item Number

SKU	GTIN
272M-17	0841683120667
272M-18	0841683120674
272M-14	0841683120636
272M-16-RUO	04061836542610
272M-15	0841683120643
272M-16	0841683120650

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