283M-1
HBME-1 (HBME-1) Mouse Monoclonal Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
HBME-1, monoclonal
Application:
IHC (p)
Citations:
6
biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
HBME-1, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (283M-14), vial of 0.5 mL concentrate (283M-15), bottle of 1.0 mL predilute (283M-17), vial of 1.0 mL concentrate (283M-16), bottle of 7.0 mL predilute (283M-18)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgMκ
control
mesothelioma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic, membranous
General description
Hector Battifora mesothelial-1 (HBME-1) is a membrane antigen that exists in the microvilli ofmesothelial cells and other epithelial cells. Anti-HBME-1 labels thyroid papillary carcinomaand follicular carcinoma but not normal thyroid making it a valuable marker for distinguishingthyroid malignancies from benign thyroid lesions. It has also been demonstrated to labelmesothelial cells, both benign and malignant (malignant mesothelioma), and thus can aid inthe identification of mesothelioma.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
HBME-1 Positive Control Slides, Product No. 283S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Regulatory Information
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A C Bateman et al.
Histopathology, 30(1), 49-56 (1997-01-01)
Histological diagnosis of malignant mesothelioma and differentiation from adenocarcinoma is often difficult. Definitive pathological confirmation of malignant mesothelioma requires demonstration of an appropriate immunohistochemical phenotype. Selection of an optimum panel of immunohistochemical antibodies for the reliable identification of malignant mesothelioma
J E Barroeta et al.
Endocrine pathology, 17(3), 225-234 (2007-02-20)
Several immunohistochemical markers have been used to aid in the diagnosis of follicular-derived lesions of the thyroid (FDLT). In this study we analyze the diagnostic efficacy of an immunopanel of antibodies to cytokeratin-19 (CK19), galectin-3 (GAL-3), HBME-1, anti-MAP kinase (ERK)
Daniela Cabibi et al.
Thyroid : official journal of the American Thyroid Association, 17(7), 603-607 (2007-08-19)
To verify whether immunohistochemistry might be useful in the distinction between a true laterocervical metastasis of an undetected thyroid carcinoma and a primary tumor outside the gland. Galectin-3, cytokeratin 19, and HBME-1 were assessed in six cases (group A) of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 283M-18 | 0841683133032 |
| 283M-17 | 0841683133025 |
| 283M-14 | 0841683132998 |
| 283M-16 | 0841683133018 |
| 283M-15 | 0841683133001 |