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284M-9

Microphthalmia Transcription Factor (MiTF) (C5/D5) Mouse Monoclonal Antibody

Name: Microphthalmia Transcription Factor (MiTF) (C5/D5) Mouse Monoclonal Antibody
Brand: SIGMA

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

C5/D5, monoclonal

Application:

IHC (p)

Citations:

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biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

C5/D5, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (284M-94), vial of 0.5 mL concentrate (284M-95), bottle of 1.0 mL predilute (284M-97), vial of 1.0 mL concentrate (284M-96), bottle of 7.0 mL predilute (284M-98)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

melanoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... MITF(4286)

Related Categories

Cell Marque

Cell Marque™ Primary Antibodies

Clinical & Diagnostics

General description

Mi is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of Mi exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma, and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Microphthalmia Transcription Factor (MiTF) Positive Control Slides, Product No. 284S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Immunohistochemical characteristics of melanoma.

Steven J Ohsie et al.

Journal of cutaneous pathology, 35(5), 433-444 (2008-04-11)

Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic, mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to distinguish melanomas from these other tumors; it has also been studied for use as an adjunct to

Perivascular epithelioid cell neoplasms (PEComas): four malignant cases expanding the histopathological spectrum and a description of a unique finding.

Ilan Weinreb et al.

Virchows Archiv : an international journal of pathology, 450(4), 463-470 (2007-03-23)

Four cases of malignant PEComas were stained with smooth muscle actin, muscle specific actin, desmin, human melanoma black-45, melan-A, microphthalmia transcription factor, S100 and cyclin D1. One case was studied by electron microscopy (EM). Tumour locations were the thigh, elbow

Primary cutaneous PEComa: distinctive clear cell lesions of skin.

Bernadette Liegl et al.

The American journal of surgical pathology, 32(4), 608-614 (2008-02-19)

PEComas arising in somatic soft tissue or skin are rare. To further characterize the clinicopathologic spectrum, we herein report a series of 10 primary cutaneous PEComas. Eight patients were female and 2 patients were male. The age at presentation ranged

Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum.

Jason L Hornick et al.

The American journal of surgical pathology, 32(4), 493-501 (2008-01-29)

PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin. We

PEComa: another member of the MiT tumor family?

Alberto Righi et al.

International journal of surgical pathology, 16(1), 16-20 (2008-01-22)

We report 2 cases of PEComa, one occurring in the colon of an 11-year-old boy and the other in the bone (fibula) of a 92-year-old woman. Both tumors consisted of nests of large epithelioid cells surrounded by a fibrovascular stroma.

Articles

Immunohistochemistry in Skin Cancer

IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.

Global Trade Item Number

SKU	GTIN
284M-96	0841683133070
284M-95	0841683133063
284M-94	0841683133056
284M-97	0841683133087
284M-98	0841683133094

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