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Merck
CN

298R-1

Myosin, Smooth Muscle (EP166) Rabbit Monoclonal Primary Antibody

Synonym(s):

Smooth Muscle Myosin, heavy chain (SMM-HC)

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About This Item

UNSPSC Code:
12352203

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP166, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (298R-14)
vial of 0.1 mL concentrate Research Use Only (298R-14-RUO)
vial of 0.5 mL concentrate (298R-15)
vial of 1.0 mL concentrate (298R-16)
vial of 1.0 mL concentrate Research Use Only (298R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (298R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (298R-17)
vial of 7.0 mL pre-dilute ready-to-use (298R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (298R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

breast

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Quality Level

100
500

Gene Information

human ... MYH11(4629)

Related Categories

Analysis Note


IVD
IVD
IVD
RUO

General description

Smooth Muscle Myosin, heavy chain (SMM-HC) is a cytoplasmic structural protein that is a major component of the contractile apparatus of the smooth muscle cells. SMM-HC is also a myoepithelium-associated protein. Anti-SMM-HC is a monoclonal antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human myoepithelial cells. It is very helpful in distinguishing between benign sclerosing breast lesions and infiltrating carcinomas in difficult cases since it strongly stains the myoepithelial layer in the benign lesions while it is negative in the infiltrating carcinomas.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Myosin, Smooth Muscle Positive Control Slides, Product No. 298S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000460416
0000460416
0000401533
0000396868
0000396878

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S N Agoff et al.
Applied immunohistochemistry & molecular morphology : AIMM, 9(2), 164-169 (2001-06-09)
Distinguishing low grade endometrial stromal sarcoma (ESS) from benign smooth muscle proliferations like cellular leiomyoma (CL) can be problematic; because of differing treatments and prognosis, this distinction is important. The authors tested the hypothesis that low grade ESS could be
Nikolay K Popnikolov et al.
American journal of clinical pathology, 120(2), 161-167 (2003-08-23)
We immunohistochemically compared benign myoepithelial tumors (adenomyoepitheliomas [AMEs]) and metaplastic matrix-producing (MMP-CA) and spindle cell (MSC-CA) carcinomas of the breast to identify helpful diagnostic markers. Normal myoepithelial cells (MECs) consistently expressed cytokeratin, alpha-smooth muscle actin (SMA), myosin, S-100, CD10, and
Robert W Werling et al.
The American journal of surgical pathology, 27(1), 82-90 (2002-12-28)
Identification of myoepithelial cells using antibodies to cytoskeletal proteins, such as smooth muscle myosin heavy chain (SMM-HC) and calponin, can play an important role in distinguishing invasive carcinoma from its histologic mimics. However, antibodies to these proteins may also cross-react
D Lazard et al.
Proceedings of the National Academy of Sciences of the United States of America, 90(3), 999-1003 (1993-02-01)
The expression of several differentiation markers in normal human mammary gland myoepithelium and in certain stromal fibroblasts ("myofibroblasts") associated with breast carcinomas was studied by immunofluorescence microscopy of frozen sections. Several antibodies to smooth muscle-specific proteins (smooth muscle alpha-actin, smooth

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