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Sigma-Aldrich

Lipase Substrate

≥95% (HPLC)

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Synonym(s):
1,2-Di-O-lauryl-rac-glycero-3-(glutaric acid 6-methylresorufin ester)
Empirical Formula (Hill Notation):
C45H69NO8
CAS Number:
195833-46-6
Molecular Weight:
752.03
MDL number:
MFCD08276995
PubChem Substance ID:
57648405
NACRES:
NA.83

Quality Level

100

Assay

≥95% (HPLC)

form

powder

solubility

ethanol: soluble (10mg/mL)

fluorescence

λex 529 nm; λem 600 nm in 0.1 M Tris pH 8.4

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCCOCC(COC(=O)CCCC(=O)Oc1ccc2N=C3C=CC(=O)C(C)=C3Oc2c1)OCCCCCCCCCCCC

InChI

1S/C45H69NO8/c1-4-6-8-10-12-14-16-18-20-22-31-50-34-38(51-32-23-21-19-17-15-13-11-9-7-5-2)35-52-43(48)25-24-26-44(49)53-37-27-28-39-42(33-37)54-45-36(3)41(47)30-29-40(45)46-39/h27-30,33,38H,4-26,31-32,34-35H2,1-3H3

InChI key

FYOMYGYHAZESGQ-UHFFFAOYSA-N

General description

Lipase substrate (1,2-Di-O-lauryl-rac-glycero-3-(glutaric,acid 6-methylresorufin) ester, DGGR) is a chromogenic substrate for lipases. It is used in colorimetric methods to measure lipase activity. This substrate produces a red-purple compound, methylresorufin, upon digestion by the lipase enzyme.

Application

Lipase Substrate is used as substrate in a high‑throughput screening assay to measure the lipase activity in response to lipstatin production

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Yan Q Chen et al.
Journal of lipid research, 61(8), 1203-1220 (2020-06-04)
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate LPL. In human serum
Alexis Wilkerson et al.
Current microbiology, 77(12), 3937-3944 (2020-10-05)
Microbial assemblages in terrestrial environments, such as soils, utilize hydrolytic enzymes to function biologically in various environments including for the degradation of organic carbon compounds and cycling of nutrients that eventually contributes to the ecological and agricultural productivity of such
Ievgeniia Ostrov et al.
Food microbiology, 82, 316-324 (2019-04-28)
Biofilm-forming Bacillus species are often involved in contamination of dairy products and therefore present a major microbiological challenge in the field of food quality and safety. In this study, we sequenced and analyzed the genomes of milk- and non-milk-derived Bacillus
Michal Híreš et al.
Current microbiology, 75(5), 580-587 (2017-12-20)
Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by the European Medicines Agency (EMA). The drug is synthesized by saturation of lipstatin, a β-lactone compound, isolated from Streptomyces toxytricini
Sébastien Cadau et al.
International journal of molecular sciences, 23(21) (2022-11-12)
Atopic dermatitis (AD), the most common inflammatory skin disorder, is a multifactorial disease characterized by a genetic predisposition, epidermal barrier disruption, a strong T helper (Th) type 2 immune reaction to environmental antigens and an altered cutaneous microbiome. Microbial dysbiosis
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