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Merck
CN

30070

Cysteamine

≥98.0% (RT)

Synonym(s):

β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, MEA, Thioethanolamine

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About This Item

Linear Formula:
NH2CH2CH2SH
CAS Number:
60-23-1
Molecular Weight:
77.15
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
57648397
EC Number:
200-463-0
Beilstein/REAXYS Number:
635649
MDL number:
MFCD00008196

Key Documents

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Product Name

Cysteamine, ≥98.0% (RT)

InChI key

UFULAYFCSOUIOV-UHFFFAOYSA-N

InChI

1S/C2H7NS/c3-1-2-4/h4H,1-3H2

SMILES string

NCCS

assay

≥98.0% (RT)

storage temp.

2-8°C

Quality Level

200

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Application

Cysteamine is suitable for use:
  • in the preparation of cysteamine modified gold nanoparticles (AuNP)
  • in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
  • to enhance in vitro development of porcine oocytes matured and fertilized in vitro
  • in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange
  • as a radioprotector
  • to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content
  • as a scavenger in electrophoretic gels (acetic acid/urea gels)

Biochem/physiol Actions

Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG8927
BCCL8210
BCCH2224
BCCB5117
BCCG2678

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Successful treatment of severe paracetamol overdosage with cysteamine.
L F Prescott et al.
Lancet (London, England), 1(7858), 588-592 (1974-04-06)
W A Gahl et al.
The Biochemical journal, 228(3), 545-550 (1985-06-15)
Cystinotic lysosome-rich leucocyte granular fractions, loaded with [35S]cystine, were exposed to different cystine-depleting agents. During a 30 min incubation at 37 degrees C, untreated cystinotic granular fractions lost negligible [35S]cystine when corrected for lysosome rupture. Granular fractions exposed to 0.1
Cysteamine therapy for children with nephropathic cystinosis
Gahl WA, et al.
The New England Journal of Medicine, 316(16), 971-977 (2018)
R L Sorenson et al.
Diabetes, 32(4), 377-379 (1983-04-01)
Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treated
J Carmichael et al.
Cancer research, 47(4), 943-946 (1987-02-15)
Radiation survival curves were generated for V79 Chinese hamster and two human lung cancer cell lines (NCI-H460 and NCI-H249) with doubling times of 10, 20, and 85 h, respectively, using a standard clonogenic assay, a dye exclusion assay, and a
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