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307M-9

Cytokeratin 7 (OV-TL 12/30) Mouse Monoclonal Antibody

Name: Cytokeratin 7 (OV-TL 12/30) Mouse Monoclonal Antibody
Brand: SIGMA

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

OV-TL 12/30, monoclonal

Application:

IHC (p)

Citations:

Technical Service

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Properties

biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

OV-TL 12/30, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (307M-94), vial of 0.5 mL concentrate (307M-95), bottle of 1.0 mL predilute (307M-97), vial of 1.0 mL concentrate (307M-96), bottle of 7.0 mL predilute (307M-98)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1κ

control

lung adenocarcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT7(3855)

Description

General description

Anti-cytokeratin 7 reacts with proteins that are found in most ductal, glandular, transitional, and biliary duct epithelial cells. Cytokeratin 7 (CK7) labeling can help distinguish between lung, breast carcinomas, and urothelial carcinomas that are typically stain positive, and colon and prostate carcinomas that typically lack CK7 expression. CK7 is a common marker of primary lung adenocarcinomas and is observed in other primary lung carcinomas and non-pulmonary carcinomas. Anti-cytokeratin 7 has also been useful in the differential diagnosis of ovarianneoplasms.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note

IVD

RUO

Other Notes

Cytokeratin 7 Positive Control Slides, Product No. 307S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number

0000505143

0000518293

0000505145

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Articles

Immunohistochemistry Applications in Gastrointestinal Cancer

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

胃肠道癌症中的免疫组织化学应用

结直肠癌是男性和女性中第三大常见癌症。预计2016年将发生136,000例结直肠癌。

Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features.

W G McCluggage et al.

Histopathology, 47(3), 231-247 (2005-08-24)

The ovary is a common site of metastatic tumour. In many cases of ovarian metastasis there is a known history of malignancy but in other cases the ovarian tumour is the first manifestation of disease. In this review metastatic colorectal

Spread of prostate carcinoma to the perirectal lymph node basin: analysis of 112 rectal resections over a 10-year span for primary rectal adenocarcinoma.

Shawn K Murray et al.

The American journal of surgical pathology, 28(9), 1154-1162 (2004-08-19)

We recently identified metastatic prostate carcinoma (PCA) within perirectal lymph nodes (PLNs) from 2 patients undergoing abdominoperineal resection (APR) for rectal adenocarcinoma (RA). As this phenomenon has not been addressed by any studies in the literature and because these positive

Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implications.

Sanjay Logani et al.

The American journal of surgical pathology, 27(11), 1434-1441 (2003-10-25)

Ovarian tumors containing cells with transitional cell morphology are recognized in the 1999 World Health Organization classification of ovarian tumors and include benign Brenner tumor, borderline and malignant Brenner tumor, and transitional cell carcinoma. Recent immunohistochemical investigations have reached conflicting

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Global Trade Item Number

SKU	GTIN
307M-94	0841683134671
307M-97	0841683134701
307M-96	0841683134695
307M-96-RUO	04061836531355
307M-95	0841683134688
307M-98	0841683134718