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30906

Castor Oil, Ethoxylated

Name: Castor Oil, Ethoxylated
Brand: SIGMA

Synonym(s):

Cremophor^® ELP, ELP, PEG-35 castor oil, Polyoxyl-35 castor oil

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About This Item

CAS Number:

61791-12-6

UNSPSC Code:

12161900

NACRES:

NA.25

MDL number:

MFCD00130879

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description

non-ionic

Quality Level

100

form

paste

impurities

alkalinity, complies, ≤ acetic acid (≤0.5 g/100g (%) verfied on random samples only), ≤0.1% oleic acid, ≤0.1% palmitic acid, ≤0.2% sulfated ash (verfied on random samples only), ≤0.20% ricinoleic acid, ≤0.5% water, ≤1 ppm ethylene oxide (verfied on random samples only), ≤1.0% free fatty acids, ≤10 ppm dioxan (verfied on random samples only), ≤10 ppm heavy metals (verfied on random samples only), ≤620 ppm diethylene glycol (verfied on random samples only), ≤620 ppm ethylene glycol (verfied on random samples only)

ign. residue

≤0.2%

pH

5.0-7.0 (1 g/10 mL in H₂O)

viscosity

600-750 mPa.s(25 °C)

acid value

≤2.0 mg KOH/g

hydroxyl value

65‑78 mg KOH/g

iodine value

25‑35 g/100g

saponification value

65‑70 mg KOH/g

cation traces

K: ≤15 ppm

SMILES string

ClCC(OC(=O)N)CCl

InChI

1S/C4H7Cl2NO2/c5-1-3(2-6)9-4(7)8/h3H,1-2H2,(H2,7,8)

InChI key

JMNCUXPHXKHBPY-UHFFFAOYSA-N

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Related Categories

Biochemicals

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

Application

Castor Oil, Ethoxylated is used to emulsify and solubilize oils and other water-insoluble substances. Similar to Castor Oil, Ethoxylated but with lower water content and differences in viscosity.

Analysis Note

relative density D (25/25) 1.05-1.06

Legal Information

Cremophor is a registered trademark of BASF SE

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

494.6 °F - Not applicable

flash_point_c

257 °C - Not applicable

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Phase I and pharmacokinetic study of ABI-007, a Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel.

Nuhad K Ibrahim et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 8(5), 1038-1044 (2002-05-15)

ABI-007 is a novel Cremophor-free, protein-stabilized, nanoparticle formulation of paclitaxel. The absence of Cremophor EL may permit ABI-007 to be administered without the premedications used routinely for the prevention of hypersensitivity reactions. Furthermore, this novel formulation permits a higher paclitaxel

Allergic contact dermatitis to polyethylene glycol-7 hydrogenated castor oil.

M Kalavala et al.

Contact dermatitis, 56(5), 287-288 (2007-04-20)

Improvement of physicochemical properties of N-4472. Part II: characterization of N-4472 microemulsion and the enhanced oral absorption.

K Itoh et al.

International journal of pharmaceutics, 246(1-2), 75-83 (2002-09-25)

The optimized formulation of N-4472, N-[2-(3,5-di-tert-butyl-4-hydroxyphenethyl)-4,6-difluorophenyl]-N'-[4-(N-benzylpiperidyl)] urea, which was a poorly water-soluble drug, was developed by utilizing the complexation between N-4472 and L-ascorbic acid (VC). It was found that the formulation with Gelucire((R)) 44/14, HCO-60((R)) and sodium dodecyl sulfate provided

Novel Th1-biased adjuvant, SPO1, enhances mucosal and systemic immunogenicity of vaccines administered intranasally in mice.

Shu Yu et al.

Vaccine, 30(36), 5425-5436 (2012-06-20)

Oil-in-water emulsions are potent human adjuvants commonly used in effective pandemic influenza vaccines; however, such emulsions that can induce both Th1-biased systemic immune responses and strong mucosal immune responses via an easy method of administration are lacking. To address this

Absorption of interferon alpha from patches in rats.

Yukako Ito et al.

Journal of drug targeting, 13(6), 383-390 (2005-11-10)

Interferon alpha (IFN-alpha), patch preparations composed of three layers, water-insoluble backing layer, drug containing layer with absorption enhancer and surface layer containing pH-dependent polymer were prepared. As absorption enhancer, three surfactants, Gelucire44/14 (Lauroyl macrogol-32 glycerides), Labrasol (Caprylocaproyl macrogol-8 glycerides) and

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Global Trade Item Number

SKU	GTIN
30906-1KG	04061826675250

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