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Merck
CN

320M-1

Cytokeratin 20 (Ks20.8) Mouse Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
Ks20.8, monoclonal
Application:
IHC (p)
Citations:
9
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

Ks20.8, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (320M-14), vial of 0.5 mL concentrate (320M-15), bottle of 1.0 mL predilute (320M-17), vial of 1.0 mL concentrate (320M-16), bottle of 7.0 mL predilute (320M-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:500

isotype

IgG2aκ

control

colon carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT20(54474)

General description

Cytokeratin 20 is a 46-kDa intermediate filament protein that reacts primarily with gastricand intestinal epithelium, urothelium, and Merkel cells. Anti-Cytokeratin 20 is usefulin the identification of specific types of these epithelial cells under normal, hyperplastic,and neoplastic conditions. Cytokeratin 20 has been detected in various adenocarcinomas,including those of the colon and stomach. Merkel cell carcinomas have shown reactivity. Incontrast, carcinomas of the breast are generally non-reactive.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD

IVD

IVD

RUO

Other Notes

Cytokeratin 20 Positive Control Slides , Product No. 320S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany


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Regulatory Information

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Articles

Colorectal cancer is the third most common cancer in both men and women. An estimated 136,000 cases of colorectal cancer are expected to occur in 2016.

结直肠癌是男性和女性中第三大常见癌症。预计2016年将发生136,000例结直肠癌。

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诊断性免疫组化是一系列用于识别组织异常、建立预后并提示治疗方式的技术。其基本原理是一种抗原-抗体结合反应,利用酶或荧光染料来标记抗体,呈现出组织或组织切片中特定抗原的位置和分布。

Diagnostic immunohistochemistry overview highlights its importance in cancer diagnosis and detecting infectious diseases in modern clinical pathology.


T Tot
Cancer, 85(1), 171-177 (1999-01-28)
Metastatic adenocarcinoma in the liver with an unidentified primary tumor site is a common clinical problem. Pathologists often are asked to identify the primary tumor site. The histologic picture itself usually is not helpful, because the histology may be similar
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Cancer, 92(10), 2727-2732 (2001-12-18)
Immunohistochemistry is a useful method in the differential diagnosis between pleural mesotheliomas and metastatic adenocarcinomas to the pleura. Cytokeratin (CK) 5-6 is one of the most specific mesothelioma-associated antibodies. Cytokeratin 20 and CK7 have been used successfully in studies determining
Coordinate expression of cytokeratins 7 and 20 defines unique subsets of carcinomas
Wang NP, Zee S, Zarbo RJ, Bacchi CE, Gown AM
Appl. Immunohistochem., 3, 99-107 (1995)



Global Trade Item Number

SKUGTIN
320M-140841683135609
320M-160841683135623
320M-150841683135616
320M-170841683135630
320M-16-RUO04061836532093
320M-180841683135647