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Merck
CN

33427

2,4-TDI

analytical standard

Synonym(s):

Toluene 2,4-diisocyanate, 2,4-Diisocyanatotoluene, 4-Methyl-m-phenylene diisocyanate, Tolylene 2,4-diisocyanate

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About This Item

Empirical Formula (Hill Notation):
C9H6N2O2
CAS Number:
584-84-9
Molecular Weight:
174.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329754539
EC Number:
209-544-5
Beilstein/REAXYS Number:
744602
MDL number:
MFCD00002011

Key Documents

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Product Name

2,4-TDI, analytical standard

InChI key

DVKJHBMWWAPEIU-UHFFFAOYSA-N

InChI

1S/C9H6N2O2/c1-7-2-3-8(10-5-12)4-9(7)11-6-13/h2-4H,1H3

SMILES string

Cc1ccc(cc1N=C=O)N=C=O

grade

analytical standard

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

124-126 °C/18 mmHg (lit.)
251 °C (lit.)

mp

19.5-21.5 °C (lit.)

density

1.22 g/mL at 20 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

storage temp.

room temp

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Application

2,4-TDI may be used as an analytical reference standard for the quantification of the analyte in gas-phase and biological fluids using chromatography techniques.

General description

2,4-TDI is an environmental contaminant belonging to the class of diisocyanates. It is commercially used as a starting material for varnishes, paints, elastomers, polyurethane foams, wire enamels, etc.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food.

Find all available reference materials for compounds listed in 10/2011 here

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

269.6 °F - closed cup

flash_point_c

132 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCL0795
BCCK8861
BCCG2951
BCCF0512
BCCF0513

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Biological monitoring of occupational exposure to toluene diisocyanate: measurement of toluenediamine in hydrolysed urine and plasma by gas chromatography-mass spectrometry
Persson P, et al.
Occupational and Environmental Medicine, 50(12), 1111-1118 (1993)
Determination of gas-phase produced ethyl parathion and toluene 2, 4-diisocyanate by ion mobility spectrometry, gas chromatography and liquid chromatography
Nousiainen M, et al.
Talanta, 72(3), 984-990 (2007)
Tatiana Kuznetsova et al.
American journal of hypertension, 28(4), 535-545 (2014-09-23)
The cardio-renal interaction occurs via hemodynamic and humoral factors. Noninvasive assessment of renal hemodynamics is currently possible by assessment of renal resistive index (RRI) derived from intrarenal Doppler arterial waveforms as ((peak systolic velocity - end-diastolic velocity)/peak systolic velocity). Limited
Norman Mangner et al.
JACC. Cardiovascular imaging, 7(12), 1198-1205 (2014-10-13)
The aim of our study was to assess geometric and functional changes of the heart in obese compared with nonobese children and adolescents. Obesity in children and adolescents has increased over the past decades and is considered a strong risk
Olov Collste et al.
Journal of cardiac failure, 20(12), 968-972 (2014-10-01)
Our objective was to investigate whether dobutamine stress echocardiography (DSE) could induce abnormal cardiac function in takotsubo stress cardiomyopathy (TSC) patients in a stable condition after the acute attack. This was a case-control study and a substudy of the Stockholm
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