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344M-9

Tyrosinase (T311) Mouse Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
T311, monoclonal
Application:
IHC (p)
Citations:
8
Technical Service
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biological source

mouse

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

T311, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (344M-94), vial of 0.5 mL concentrate (344M-95), bottle of 1.0 mL predilute (344M-97), vial of 1.0 mL concentrate (344M-96), bottle of 7.0 mL predilute (344M-98)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG2a

control

melanoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... TYR(7299)

General description

Tyrosinase is an enzyme, amongst a family of enzymes, which is involved in the biosynthesis of melanin. Anti-tyrosinase has been found to be quite specific for melanotic lesions such as malignant melanoma and melanotic neurofibroma. Essentially no carcinomas express this marker.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Tyrosinase Positive Control Slides, Product No. 344S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000528628
0000528628
0000487847
0000487843
0000487843

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Articles

Immunohistochemistry in Skin Cancer

IHC antibodies enhance dermatopathology beyond H&E stained slides, improving techniques and applications for dermatological research.

Nele Jaanson et al.
Melanoma research, 13(5), 473-482 (2003-09-27)
Tyrosinase, the critical enzyme in melanin synthesis, is also found to be expressed in most malignant melanomas and can serve as a target for the immune response by both CD4+ and CD8+ T-cells. Therefore it could be used as a
K J Busam et al.
The American Journal of dermatopathology, 22(3), 237-241 (2000-06-28)
Histiocytic tumors can be confused with melanocytic nevi and malignant melanoma and vice versa. To explore the use of immunohistochemistry for this diagnostic problem, we examined the expression of S-100 protein, gp100 (the antigen recognized by HMB-45), tyrosinase (T311), Melan-A
C B Meije et al.
The Journal of pathology, 190(5), 572-578 (2000-03-23)
The in situ expression of antigens associated with melanosomes (gp-100), pigmentation (PAA), tyrosinase (TRP-1), melanoma (MAA-1/MAA-2), and HLA-DR was investigated immunohistochemically in frozen archival specimens of common acquired melanocytic naevi, in dysplastic melanocytic naevi, and in lymph node metastases of
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Global Trade Item Number

SKUGTIN
344M-960841683137436
344M-970841683137443
344M-950841683137429
344M-980841683137450
344M-940841683137412