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356R-1

Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody

Name: Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

Synonym(s):

CK 5/6, cytokeratin 5/6

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP24 & EP67, monoclonal

Application:

IHC (p)

Citations:

Technical Service

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Properties

biological source

rabbit

Quality Level

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP24 & EP67, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (356R-14), vial of 0.1 mL concentrate Research Use Only (356R-14-RUO), vial of 0.5 mL concentrate (356R-15), vial of 1.0 mL concentrate (356R-16), vial of 1.0 mL concentrate Research Use Only (356R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (356R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (356R-17), vial of 7.0 mL pre-dilute ready-to-use (356R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (356R-18-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

control

mesothelioma, prostate, squamous cell carcinoma ((lung))

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... KRT5(3852)

Description

General description

Twenty identified cytokeratins make up a complex family of intermediate filaments.¹ Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.^1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.¹

Physical form

Solution in Tris buffer, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide

Preparation Note

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Analysis Note

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Other Notes

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

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Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control.

R Lersch et al.

Molecular and cellular biology, 9(9), 3685-3697 (1989-09-01)

The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin K5 (58 kilodaltons) and its corresponding partner

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

K Takahashi et al.

The Journal of biological chemistry, 270(31), 18581-18592 (1995-08-04)

The human type II keratin 6 (K6; 56 kDa) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or

Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.

Ordo?ez, N.G.

Modern Pathology, 15, 6-10 (2002)

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Global Trade Item Number

SKU	GTIN
356R-14	0841683105633
356R-14-RUO	04061836545734
356R-17-RUO	04061836545796
356R-16	0841683105664
356R-18-RUO	04061836545819
356R-16-RUO	04061836545772
356R-17	0841683105671
356R-15-RUO	04061836545758
356R-18	0841683105657
356R-15	0841683105688