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Merck
CN

383R-1

SOX-10 (EP268) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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Technical Service
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biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP268, monoclonal

description

(For In Vitro Diagnostic Use in Select Regions (See Chart))

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (383R-14)
vial of 0.5 mL concentrate (383R-15)
bottle of 1.0 mL predilute (383R-17)
vial of 1.0 mL concentrate (383R-16)
bottle of 7.0 mL predilute (383R-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200

isotype

IgG

control

melanoma, skin melanocytes

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... SOX10(6663)

Related Categories

General description

Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development and acts as a nucleocytoplasmic shuttle protein. SOX-10 is expressed in melanocytic lineages and is a sensitive melanoma marker for conventional, and desmoplastic subtypes. In normal tissues, SOX-10 is expressed in melanocytes and myoepithelial cells.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
SOX-10 Positive Control Slides, Product No. 383S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000509530
0000509532
0000509530
0000509532
0000509533

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A Robson et al.
Histopathology, 38(2), 135-140 (2001-02-24)
The histological distinction of desmoplastic melanoma from cutaneous scar tissue, particularly in the context of re-excision specimens or possible recurrence, may be very difficult. Immunostaining for S100 protein is often used to discriminate although there are little data on S100
Joe A Chorny et al.
The American Journal of dermatopathology, 24(4), 309-312 (2002-07-27)
Distinguishing desmoplastic melanoma (DM) from scar tissue on routine microscopy can be difficult, especially in re-excision specimens, and S100 immunohistochemistry has been recommended as a useful adjunct. The purpose of this study is to evaluate the extent and nature of
T A Longacre et al.
The American journal of surgical pathology, 20(12), 1489-1500 (1996-12-01)
The clinical, histologic, and immunohistologic features of 22 desmoplastic melanomas (DMM), 10 mixed desmoplastic and spindle-cell melanomas (DMM/SMM), and two cellular spindle-cell melanomas (SMM) were studied. Patients ranged in age from 35 to 91 years (mean, 67) and included 23
Daisuke Nonaka et al.
The American journal of surgical pathology, 32(9), 1291-1298 (2008-07-19)
S100 protein is a sensitive marker for melanomas and peripheral nerve sheath tumors. It is, however, expressed by other mesenchymal and epithelial tumors. Despite its low specificity, S100 protein is valuable for the diagnosis of desmoplastic melanomas and peripheral nerve
Frances Ivette Ramos-Herberth et al.
Journal of cutaneous pathology, 37(9), 944-952 (2010-07-27)
Sry-related HMG-BOX gene 10 (SOX10), a nuclear transcription factor that plays an important role in schwannian and melanocytic cell differentiation, has recently been shown to be a useful marker in the diagnosis of melanocytic and schwannian tumors. Fibroblasts and histiocytes
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