389M-1
Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352116
Conjugate:
unconjugated
Clone:
GS-6, monoclonal
Application:
IHC (p)
Citations:
2
biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
GS-6, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (389M-14), vial of 0.5 mL concentrate (389M-15), bottle of 1.0 mL predilute (389M-17), vial of 1.0 mL concentrate (389M-16), bottle of 7.0 mL predilute (389M-18)
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
isotype
IgG2a
control
hepatocellular carcinoma
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic
Gene Information
human ... GLUL(2752)
General description
Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver. In normal liver, GS expression is seen in centrilobular (zone 3) hepatocytes, but not in mid-zone (zone 2) or periportal (zone 3) hepatocytes. Glutamine synthetase immunohistochemistry is also positive in neoplasms of hepatocyte origin, such as hepatocellular carcinoma (HCC) and hepatocellular adenoma, making it useful for identifying these tumors.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Glutamine Synthetase Positive Control Slides, Product No. 389S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
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Regulatory Information
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Luca Di Tommaso et al.
Hepatology (Baltimore, Md.), 45(3), 725-734 (2007-02-28)
Hepatocellular nodules in cirrhosis include regenerative (large regenerative, LRN) and dysplastic (low and high grade, LGDN and HGDN) nodules, early and grade 1 HCC (eHCC-G1), and overt HCC. The differential diagnosis may be particularly difficult when lesions such as HGDN
Jiakun Chen et al.
Neuron, 112(1), 93-112 (2023-12-15)
Astrocytes play crucial roles in regulating neural circuit function by forming a dense network of synapse-associated membrane specializations, but signaling pathways regulating astrocyte morphogenesis remain poorly defined. Here, we show the Drosophila lipid-binding G protein-coupled receptor (GPCR) Tre1 is required
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 389M-18 | 0841683140443 |
| 389M-14 | 0841683140405 |
| 389M-15 | 0841683140412 |
| 389M-16 | 0841683140429 |
| 389M-16-RUO | 04061836547004 |
| 389M-17 | 0841683140436 |