403A-7
C3d Rabbit Polyclonal Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p)
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (403A-74), vial of 0.5 mL concentrate (403A-75), bottle of 1.0 mL predilute (403A-77), vial of 1.0 mL concentrate (403A-76), bottle of 7.0 mL predilute (403A-78)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
shipped in
wet ice
storage temp.
2-8°C
visualization
cytoplasmic, membranous
Gene Information
human ... CR2(1380)
General description
Complement component C3 is an integral part of the classical, lectin, and alternative complement pathways, and its cleavage products are involved in immune responses such as opsonization and cell lysis. C3d is a fragment of C3 that normally binds to pathogen surfaces to promote B-cell activation. However, deposition of C3d has also been observed in peritubular capillaries of transplanted kidneys undergoing acute allograft rejection.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
C3d Positive Control Slides, Product No. 403S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Regulatory Information
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Dirk R J Kuypers et al.
Transplantation, 76(1), 102-108 (2003-07-17)
C4d deposition in peritubular capillaries (PTCs) is a sign of humoral renal allograft rejection and an independent predictor of graft survival. Few investigators have focused on the meaning of capillary C3 deposition in rejecting grafts. Because C3 production can result
Alice Bickerstaff et al.
The American journal of pathology, 173(2), 347-357 (2008-06-28)
Acute humoral rejection (AHR), which occurs in up to 8% of kidney transplant recipients, is a significant cause of renal allograft dysfunction and loss. More efficacious treatment modalities are needed to eliminate or curtail alloantibody production and its deleterious effects
G Eggertsen et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 109(12), 825-834 (2002-02-16)
Among patients with early severe impairment of renal allograft function we have previously identified a group displaying isolated deposition of complement factor C3 in glomeruli. Here we studied the pattern of complement deposition more extensively in allograft biopsies from five
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 403A-74 | 0841683141235 |
| 403A-75 | 0841683141242 |
| 403A-78 | 0841683141273 |
| 403A-76 | 0841683141259 |
| 403A-77 | 0841683141266 |