Skip to Content
Merck
CN

Key Documents

View All Documentation

41111

Ajmalicine

≥98.0% (HPLC)

Synonym(s):

δ-Yohimbine, Py-Tetrahydroserpentine, Raubasine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C21H24N2O3
CAS Number:
483-04-5
Molecular Weight:
352.43
MDL number:
MFCD00042748
UNSPSC Code:
12352200
EC Number:
207-589-5
NACRES:
NA.25
Beilstein/REAXYS Number:
97268
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

assay

≥98.0% (HPLC)

optical activity

[α]/D -65±3°, c = 1 in chloroform

mp

~258 °C (dec.)

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

N21[C@@H](C[C@H]5[C@@H]([C@@H](OC=C5C(=O)OC)C)C2)c3[nH]c4c(c3CC1)cccc4

InChI

1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1

InChI key

GRTOGORTSDXSFK-XJTZBENFSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Ajmalicine (δ-Yohimbine, Py-Tetrahydroserpentine, Raubasine) is an alkaloid used to study its effects as an antagonist of adrenergic and nicotinic receptors.

Biochem/physiol Actions

Metabolite in the indole alkaloid biosynthesis (serpentine production); found naturally in various plants such as Rauwolfia spp., Catharanthus roseus, and Mitragyna speciosa. It shows antimicrobial activity, and is used as an anti-hypertensive and sedative.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

涉药品监管产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCBF4162
BCBF4162V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Trends for diverse production strategies of plant medicinal alkaloids.
Liuqing Yang et al.
Natural product reports, 27(10), 1469-1479 (2010-08-24)
Catharanthus alkaloids and their enhanced production using elicitors: a review.
Gautam, S., et al.
International Journal of Pharmacy and Technology, 3, 713-724 (2011)
Roberts, M. F.
Alkaloids: biochemistry, ecology, and medicinal applications, 450-450 (1998)
Francisco León et al.
Natural product communications, 4(7), 907-910 (2009-09-08)
Mitragyna speciosa (Rubiaceae) has traditionally been used in the tropical regions of Asia, Africa and Indonesia as a substitute for opium. Indole alkaloids are the most common compounds that have been isolated. We investigated the constituents of the leaves of
P Demichel et al.
British journal of pharmacology, 83(2), 505-510 (1984-10-01)
The actions of raubasine, tetrahydroalstonine and akuammigine were studied on pre- and postsynaptic alpha-adrenoceptors of the rat vas deferens. These three drugs competitively antagonized the effect of noradrenaline on postsynaptic alpha-adrenoceptors, yielding pA2 values of 6.57, 4.56 and 4.68 respectively.
View All Related Papers

Global Trade Item Number

SKUGTIN
41111-10MG04061832071893
41111-50MG04061832071909

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service