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Sigma-Aldrich

Dimethyl sulfoxide

BioUltra, for molecular biology, ≥99.5% (GC)

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Synonym(s):
DMSO
Linear Formula:
(CH3)2SO
CAS Number:
67-68-5
Molecular Weight:
78.13
Beilstein:
506008
EC Number:
200-664-3
MDL number:
MFCD00002089
PubChem Substance ID:
57650076
NACRES:
NA.25

grade

for molecular biology

Quality Level

200

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

product line

BioUltra

Assay

≥99.5% (GC)

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

impurities

Dnases, none detected
 RNases, none detected
 insoluble matter, passes filter test
 phosphatases, none detected
 proteases, none detected
≤0.001% free acid (as CH3COOH)

evapn. residue

≤0.005%

color

colorless

refractive index

n20/D 1.479 (lit.)
n20/D 1.479

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

cation traces

Al: ≤0.5 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.5 mg/kg
K: ≤0.5 mg/kg
Li: ≤0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤1 mg/kg
Ni: ≤0.5 mg/kg
Pb: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string

CS(C)=O

λ

neat

UV absorption

λ: 280 nm Amax: 0.22

suitability

suitable for molecular biology

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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General description

Dimethyl sulfoxide (DMSO) is an effective aprotic solvent. It is colorless, odorless and hygroscopic in nature. DMSO enhance the permeability of various hydrophilic and lipophilic permeants. It is one of the widely used solvents in the laboratory.

Application

Dimethyl sulfoxide (DMSO) has been used as a vehicle for test compounds in various experimental studies. It has also been used as a solvent during amyloid β (Aβ) aggregation protocol for resolubilization of peptide to maintain its dissociated state.

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Other Notes

Polybrene / DMSO-assisted gene transfer

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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  1. What is the molarity of DMSO?

    DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

  2. What is the DMSO dissolved in?

    DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

  3. Where does DMSO come from?

    DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

  4. Does DMSO have any synthetic utility?

    DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

  5. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  6. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

  7. What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

    DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.

  8. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  9. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  10. What is Sure/Seal™ packaging?

    The Aldrich Sure/Seal™ packaging system is useful in the handling and storage of air-sensitive reagents.

  11. Is Dimethyl sulfoxide a sterile product?

    No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

  12. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  13. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

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Biotechniques, 78(1), 17-21 (2003)
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Lantz-McPeak S, et al.
Journal of Applied Toxicology, 35(3), 261-272 (2015)
R Aubin et al.
Methods in molecular biology (Clifton, N.J.), 7, 35-43 (1991-01-01)
Efforts to expand the current repertory of cell types amenable to transfection have often been thwarted by a common obstacle-namely, the low tolerance displayed by the recipient cells toward the gene-transfer regimen itself. As a result, several laboratories have turned
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