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422R-1

PHOX2B (EP312) Rabbit Monoclonal Primary Antibody

Name: PHOX2B (EP312) Rabbit Monoclonal Primary Antibody
Brand: SIGMA

Synonym(s):

Paired-like Homeobox 2B

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About This Item

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP312, monoclonal

Application:

IHC (p)

Citations:

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Properties

biological source

rabbit

Quality Segment

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP312, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (422R-14), vial of 0.1 mL concentrate Research Use Only (422R-14-RUO), vial of 0.5 mL concentrate (422R-15), vial of 1.0 mL concentrate (422R-16), vial of 1.0 mL concentrate Research Use Only (422R-16-RUO), vial of 1.0 mL pre-dilute Research Use Only (422R-17-RUO), vial of 1.0 mL pre-dilute ready-to-use (422R-17), vial of 7.0 mL pre-dilute ready-to-use (422R-18), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (422R-18-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

neuroblastoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... PHOX2B(8929)

Description

General description

Paired-like homeobox 2B (PHOX2B) is a transcription factor located on chromosome 4p13 which is crucial to the formation of autonomic ganglia in the autonomic nervous system (ANS). PHOX2B gene is strictly expressed in neural crest derivatives committed to the noradrenergic phenotype. The PHOX2B gene encodes a paired-like homeo-domain transcription factor with an extra-axial expression pattern restricted to the ANS. Neuroblasts of peripheral neuroblastic tumors are derived from the sympathoadrenal lineage, a division of the ANS. PHOX2B has been observed in peripheral neuroblastic tumors, neuroblastomas, paragangliomas, ganglioneuroblastomas, ganglioneuromas and pheochromocytomas. PHOX2B has been reported to be negative in other small round blue cell tumors.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

IVD

RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

PHOX2B Positive Control Slides, Product No. 422S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c