44714
(S)-Mevalonic acid lithium salt
≥96.0% (GC)
Synonym(s):
Lithium (S)-3,5-dihydroxy-3-methyl-pentanoate, Lithium (S)-3,5-dihydroxy-3-methyl-valerate, S-MVA-Li
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About This Item
Empirical Formula (Hill Notation):
C6H12O4 · xLi+
CAS Number:
Molecular Weight:
148.16 (free acid basis)
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.25
Assay:
≥96.0% (GC)
Quality level:
Quality Level
assay
≥96.0% (GC)
optical activity
[α]/D +25.0±3.0°, c = 0.1 in 1 M HCl
storage temp.
2-8°C
SMILES string
O[C@@](CCO)(CC(=O)O)C
InChI
1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m0/s1
InChI key
KJTLQQUUPVSXIM-LURJTMIESA-N
Biochem/physiol Actions
Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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R R Kopito et al.
Journal of lipid research, 23(4), 577-583 (1982-05-01)
A circadian rhythm in plasma mevalonate was identified in human subjects. This variation, over a 5-fold range, is paralleled by a rhythm in urinary excretion. No such diurnal change in plasma mevalonate was observed in schedule-fed, light-cycled rats, despite the
R A Larson et al.
Blood, 64(1), 257-262 (1984-07-01)
Mevalonic acid can stimulate leukemic cells from some patients with B cell chronic lymphocytic leukemia (CLL) to enter the cell cycle in vitro and to synthesize DNA. Unlike normal human peripheral blood lymphocytes, which require the presence of granulocytes for
Le-Le Hu et al.
PloS one, 6(12), e29491-e29491 (2012-01-06)
Given a compound, how can we effectively predict its biological function? It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biological processes and provide useful clues for drug design. In this
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 44714-50MG | 04061832404400 |
| 44714-10MG | 04061832404394 |