457M-9
p57Kip2 (Kp10) Mouse Monoclonal Antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
Kp10, monoclonal
Application:
IHC (p)
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
culture supernatant
antibody product type
primary antibodies
clone
Kp10, monoclonal
description
For In Vitro Diagnostic Use in Select Regions (See Chart)
form
buffered aqueous solution
species reactivity
human
packaging
vial of 0.1 mL concentrate (457M-94), vial of 0.5 mL concentrate (457M-95), bottle of 1.0 mL predilute (457M-97), vial of 1.0 mL concentrate (457M-96), bottle of 7.0 mL predilute (457M-98)
manufacturer/tradename
Cell Marque®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
isotype
IgG2bκ
control
placenta
shipped in
wet ice
storage temp.
2-8°C
visualization
nuclear
Gene Information
human ... CDKN1C(1028)
General description
Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In normal placenta, cytotrophoblast, syncytio trophoblast, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
p57 is a human tumor suppressor gene encoded on the 11p15.5 chromosomal sequence. Anti-p57 has been used as an aid in discriminating complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts or stromal cells) from partial hydatidiform mole (PHM) (nuclear staining of both cytotrophoblasts and stromal cells) and hydropic abortion. In the normal placenta, cytotrophoblast, intermediate trophoblast and decidual cells, and stromal cells are labeled with this antibody. Intervillous trophoblastic islands demonstrate nuclear labeling in all entities and serve as an internal control.
Physical form
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Preparation Note
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
Analysis Note
 IVD |  IVD |  IVD |  RUO |
Other Notes
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
P57Kip2 Positive Control Slides, Product No. 457S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
Legal Information
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
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Regulatory Information
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S-Y Jun et al.
Histopathology, 43(1), 17-25 (2003-06-26)
To determine the utility of p57kip2 in the diagnosis of hydatidiform mole. p57kip2 protein is a cyclin-dependent kinase inhibitor (CDKI) and is strongly paternally imprinted, being expressed from the maternal allele. It has been hypothesized that complete mole (CHM) with
Maki Kihara et al.
The Journal of reproductive medicine, 50(5), 307-312 (2005-06-24)
To evaluate whether p57KIP2 expression is concordant with the result of DNA polymorphism analysis in molar pregnancy. Eleven molar pregnancies diagnosed by pathologic findings between October 2002 and April 2004 were studied. Histopathologic diagnosis, DNA polymorphism analysis and p57KIP2 immunohistochemistry
Rita L Romaguera et al.
Fetal and pediatric pathology, 23(2-3), 181-190 (2005-03-17)
Classification of molar gestations into complete and partial and their differentiation from hydropic abortions traditionally are accomplished by morphology alone. The process sometimes may be inaccurate or inconclusive. With the availability of p57 immunostaining it may be possible to objectively
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 457M-94 | 0841683142805 |
| 457M-96 | 0841683142829 |
| 457M-95 | 0841683142812 |
| 457M-96-RUO | 04061836535230 |
| 457M-98 | 0841683142843 |
| 457M-97 | 0841683142836 |