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46123

1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide

suitable for fluorescence, ≥97.0% (TLC)

Synonym(s):

(6-Methoxyquinolinio)acetic acid ethyl ester bromide, MQAE

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About This Item

Empirical Formula (Hill Notation):
C14H16BrNO3
CAS Number:
162558-52-3
Molecular Weight:
326.19
NACRES:
NA.32
PubChem Substance ID:
329757076
UNSPSC Code:
12352106
MDL number:
MFCD00467854
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Quality Level

100

assay

≥97.0% (TLC)

form

solid

mp

177-179 °C (lit.)

solubility

DMSO: soluble, H2O: soluble, methanol: soluble

fluorescence

λex 350 nm; λem 460 nm in 0.1 M borate pH 8.0 (quenching with Cl-)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

[Br-].CCOC(=O)C[n+]1cccc2cc(OC)ccc12

InChI

1S/C14H16NO3.BrH/c1-3-18-14(16)10-15-8-4-5-11-9-12(17-2)6-7-13(11)15;/h4-9H,3,10H2,1-2H3;1H/q+1;/p-1

InChI key

DSLLHVISNOIYHR-UHFFFAOYSA-M

Application

1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide, a fluorescent chloride indicator dye, may be used to measure intracellular and extracellular chloride concentrations.

Other Notes

Improved chloride probe. Used to measure chloride transport in liposome membranes

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH7936
BCCC2630
BCBT8979
BCBM3698V
BCBL4880V

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Articles

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感应染料

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Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mucosal function through inhibition of chloride secretion. However, the molecular mechanisms underlying this observation are
Tamer Coskun et al.
American journal of physiology. Gastrointestinal and liver physiology, 283(5), G1147-G1155 (2002-10-17)
Gastric secretion of hydrochloric acid requires protons and chloride, yet the mechanisms and regulation of gastric chloride secretion remain unclear. We developed an in vivo technique to simultaneously measure acid/base and chloride secretion into the gastric lumen of anesthetized rats.
A S Verkman et al.
Analytical biochemistry, 178(2), 355-361 (1989-05-01)
A class of N-substituted quinoline compounds has been introduced recently for the fluorescence measurement of Cl concentration in biological preparations. The most Cl-sensitive compound was 6-methoxy-N-[3-sulfopropyl] quinolinium with peak excitation and emission wavelengths of 350 and 442 nm and a
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Global Trade Item Number

SKUGTIN
46123-100MG-F04061833277225