47190
5-Fluoroorotic acid hydrate
≥99.0% (TLC)
Synonym(s):
2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid, 5-Fluorouracil-4-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C5H3FN2O4 · xH2O
CAS Number:
Molecular Weight:
174.09 (anhydrous basis)
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
211-876-0
MDL number:
Quality Level
assay
≥99.0% (TLC)
form
solid
mp
278 °C (dec.) (lit.)
solubility
4 M NH4OH: 50 mg/mL, clear, faintly yellow
storage temp.
−20°C
SMILES string
OC(C(NC(N1)=O)=C(F)C1=O)=O.[H]O[H]
InChI
1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2
InChI key
LODRRYMGPWQCTR-UHFFFAOYSA-N
Application
Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
Other Notes
Selective agent in yeast molecular genetics
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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J D Boeke et al.
Methods in enzymology, 154, 164-175 (1987-01-01)
5-FOA is an extremely useful reagent for the selection of Ura- cells amid a population of Ura+ cells. The selection is effective in transformation and recombination studies where loss of URA3+ is desired. A new plasmid shuffling procedure based on
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 47190-1G-F | 04061826010310 |
| 47190-250MG-F | 04061832404424 |