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475R-9

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

Name: INSM1 (MRQ-70) Rabbit Monoclonal Antibody
Brand: SIGMA

Synonym(s):

Insulinoma-associated protein 1

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About This Item

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

MRQ-70, monoclonal

Application:

IHC (p)

Citations:

Technical Service

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Properties

biological source

rabbit

Quality Segment

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-70, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (475R-94), vial of 0.1 mL concentrate Research Use Only (475R-94-RUO), vial of 0.5 mL concentrate (475R-95), vial of 1.0 mL concentrate (475R-96), vial of 1.0 mL concentrate Research Use Only (475R-96-RUO), vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO), vial of 1.0 mL pre-dilute ready-to-use (475R-97), vial of 7.0 mL pre-dilute ready-to-use (475R-98), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

pancreas

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Description

General description

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor¹. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract^2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression^5-6.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c