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478M-9

CDK4 (DCS-31) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
DCS-31, monoclonal
Application:
IHC (p)
Citations:
3
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biological source

mouse

Quality Segment

100, 500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

DCS-31, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (478M-94), vial of 0.1 mL concentrate Research Use Only (478M-94-RUO), vial of 0.5 mL concentrate (478M-95), vial of 1.0 mL concentrate (478M-96), vial of 1.0 mL concentrate Research Use Only (478M-96-RUO), vial of 1.0 mL pre-dilute Research Use Only (478M-97-RUO), vial of 1.0 mL pre-dilute ready-to-use (478M-97), vial of 7.0 mL pre-dilute ready-to-use (478M-98), vial of 7.0 mL pre-dilute ready-to-use Research Use Only (478M-98-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

isotype

IgG

control

dedifferentiated liposarcoma, well-differentiated liposarcoma

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

General description

Well-differentiated liposarcoma is a malignant, non-metastasizing tumor that can present with similar histological characteristics as benign lipoma lesions and has a higher recurrence rate. The CDK4 protein is frequently overexpressed in well-differentiated liposarcoma due to gene amplification of the 12q13-15 chromosomal region that harbors the CDK4 gene, but amplification and subsequent overexpression is rarely observed in lipomas. Due to CDK4 protein expression differences between these lesions, anti-CDK4 antibody can be used in an immunohistochemistry panel as an aid in the differential diagnosis between well-differentiated liposarcoma and lipoma.1,2,3

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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