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490M-1

Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody

Name: Tyrosine Hydroxylase (LNC1) Mouse Monoclonal Antibody
Brand: SIGMA

Synonym(s):

TYH

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About This Item

UNSPSC Code:

41116161

Conjugate:

unconjugated

Clone:

LNC1

Application:

IHC

Citations:

Technical Service

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Properties

biological source

(Mouse)

Quality Segment

500

conjugate

unconjugated

antibody form

(IgG1 Supernatant)

antibody product type

primary antibodies

clone

LNC1

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL (concentrate (490M-14)), vial of 0.1 mL (concentrate (490M-14-RUO) Research Use Only), vial of 0.5 mL (concentrate (490M-15)), vial of 1.0 mL (concentrate (490M-16)), vial of 1.0 mL (concentrate (490M-16-RUO) Research Use Only), vial of 1.0 mL (pre-dilute (490M-17-RUO) Research Use Only), vial of 1.0 mL (pre-dilute ready-to-use (490M-17)), vial of 7.0 mL (pre-dilute ready-to-use (490M-18)), vial of 7.0 mL (pre-dilute ready-to-use (490M-18-RUO) Research Use Only)

manufacturer/tradename

Cell Marque^®

technique(s)

immunohistochemistry: suitable (formalin-fixed, paraffin-embedded sections 1:25-1:100 (concentrated))

isotype

IgG1

control

neuroblastoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Description

General description

Tyrosine Hydroxylase (TYH) is the rate-limiting enzyme of catecholamine biosynthesiss. TYH uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-DOPA, a precursor to dopamine. Anti-TYH is sensitive and specific for peripheral neuroblastic tumors in the differential diagnosis from other tumors of childhood and shows high diagnostic utility. Anti-TYH has been shown to positively label all pheochromocytomas and sympathetic paragangliomas, and thus aids in differentiating them from their histologic mimics such as adrenocortical neoplasms.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Analysis Note

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c