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Merck
CN

49667

4-(Maleinimido)phenyl isocyanate

purum, ≥97.0% (CHN)

Synonym(s):

N-(4-Isocyanatophenyl)maleimide, PMPI

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About This Item

Empirical Formula (Hill Notation):
C11H6N2O3
CAS Number:
123457-83-0
Molecular Weight:
214.18
MDL number:
MFCD00270900
UNSPSC Code:
12352106
PubChem Substance ID:
57651217
NACRES:
NA.25

Key Documents

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grade

purum

Assay

≥97.0% (CHN)

form

solid

reaction suitability

reagent type: linker

mp

120-125 °C

functional group

maleimide

storage temp.

2-8°C

SMILES string

O=C(C=C1)N(C(C=C2)=CC=C2N=C=O)C1=O

InChI

1S/C11H6N2O3/c14-7-12-8-1-3-9(4-2-8)13-10(15)5-6-11(13)16/h1-6H

InChI key

OJQSISYVGFJJBY-UHFFFAOYSA-N

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

A novel heterobifunctional linker for hydroxyl-to-thiol coupling

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP0726
BCCM7446
BCCK6413
BCCG9658
BCCG6380

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Stéphane G Lévesque et al.
Bioconjugate chemistry, 18(3), 874-885 (2007-04-04)
Hydrogels derived from synthetic polymers have been previously engineered to degrade under the activity of matrix metalloproteinases (MMPs). It is believed that these systems can act as extracellular-matrix (ECM) equivalents mimicking the degradation and remodeling of the ECM through the
Nileshi Saraf et al.
ACS omega, 4(1), 2234-2240 (2019-02-08)
A polydimethylsiloxane-based microfluidic device has been developed for the multiplex detection of viral envelope proteins such as Zika and chikungunya on a single platform using aptamer-analyte interactions. The channel is integrated with microsized pillars that increase the surface area allowing
Xiang Chen et al.
Clinical laboratory, 66(3) (2020-03-13)
Vitamin B12 is very important for the human body. Early diagnosis of vitamin B12 deficiency is essential because it is associated with many problems such as fatigue, lethargy, depression, poor memory, breathlessness, headaches, pale skin, mania, psychosis, etc. Most of
Alexis Loiseau et al.
Cancers, 11(12) (2019-12-11)
Nanohybrids based on titanate nanotubes (TiONts) were developed to fight prostate cancer by intratumoral (IT) injection, and particular attention was paid to their step-by-step synthesis. TiONts were synthesized by a hydrothermal process. To develop the customengineered nanohybrids, the surface of
M E Annunziato et al.
Bioconjugate chemistry, 4(3), 212-218 (1993-05-01)
p-Maleimidophenyl isocyanate (PMPI, 1) is a heterobifunctional cross-linking agent useful for thiol to hydroxyl coupling. Several maleimide-activated compounds were prepared and characterized and then shown to be reactive with thiol-containing proteins. Examples include activation of vitamin B12, digoxigenin, digitoxigenin, estradiol
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