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Merck
CN

50649

Glyoxal solution

BioReagent, ~40% in H2O (~8.8 M), Molecular Biology

Synonym(s):

Ethanedial, Oxalaldehyde

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About This Item

Linear Formula:
OHCCHO
CAS Number:
107-22-2
Molecular Weight:
58.04
UNSPSC Code:
12352114
NACRES:
NA.52
PubChem Substance ID:
57651264
MDL number:
MFCD00006957
Beilstein/REAXYS Number:
1732463

Key Documents

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Product Name

Glyoxal solution, BioReagent, ~40% in H2O (~8.8 M), Molecular Biology

form

liquid

InChI

1S/C2H2O2/c3-1-2-4/h1-2H

SMILES string

[H]C(=O)C([H])=O

InChI key

LEQAOMBKQFMDFZ-UHFFFAOYSA-N

grade

Molecular Biology

product line

BioReagent

concentration

~40% in H2O (~8.8 M)

impurities

DNases, none detected
 RNases, none detected
 phosphatases, none detected
 proteases, none detected

refractive index

n20/D 1.409

anion traces

chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Ca: ≤5 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤300 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

storage temp.

2-8°C

Quality Level

100

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Application

Suitable for
  • nucleic acid denaturation
  • binding of DNA/RNA to nitrocellulose membrane

Biochem/physiol Actions

Glyoxal forms stable complex with guanine residues that results in denaturation of nucleic acids.

Disclaimer

May precipitate on storage; redissolve at 50-60 °C.

General description

Glyoxal is a nucleic acid denaturant. It acts as a specific probe for homopurine strands of DNA.

Other Notes

May precipitate on storage; redissolve at 50-60 °C.
This form of glyoxal is composed of 3 moles of glyoxal and 2 moles of water in a relatively stable configuration.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCBL7249V
394949/1
367628/1
354841/1
70586/1

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R N Skopp et al.
Analytical biochemistry, 169(1), 132-137 (1988-02-15)
This paper describes agarose gel electrophoresis and silver staining of denatured RNAs. Glyoxal- or formaldehyde-denatured RNAs are electrophoresed in an agarose gel cast on a plastic support using an inert, low conductivity buffer. Following electrophoresis, the gel is stained with
Hybridization of denatured RNA transferred or dotted nitrocellulose paper.
P S Thomas
Methods in enzymology, 100, 255-266 (1983-01-01)
M Vojtisková et al.
Journal of biomolecular structure & dynamics, 5(2), 283-296 (1987-10-01)
Plasmid pEJ4, which is a derivative of pUC19 containing an insert with 60-bp-long homopurine.homopyrimidine tract from sea urchin P. miliaris histone gene spacer, was studied by chemical probes of the DNA structure osmium tetroxide and glyoxal. The former probe reacts
Catherine Lambert et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 18(1), 59-69 (2012-10-30)
The molecular basis of Alzheimer's disease has not been clearly established, but disruption of brain metal ion homeostasis, particularly copper and zinc, might be closely involved in the pathogenesis of this disease and its characteristic β-amyloid neuropathological features. The use
Yu Wang et al.
Chemical Society reviews, 41(11), 4140-4149 (2012-04-18)
Methylglyoxal (MGO) and glyoxal (GO), known as reactive carbonyl species, can be generated endogenously and exogenously (human body and food system). They are attracting increased attention because of their relationship with diabetes and flavour generation. In this review, their characteristics
View All Related Papers

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