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51120

Guanosine 5′-triphosphate sodium salt hydrate

Name: Guanosine 5&#8242;-triphosphate sodium salt hydrate
Brand: SIGMA

≥90% (HPLC), powder

Synonym(s):

GTP, GTP-Na⁺ hydrate, 5′-GTP-Na₂

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₆N₅O₁₄P₃ · xNa⁺ · yH₂O

CAS Number:

56001-37-7

Molecular Weight:

523.18 (anhydrous free acid basis)

NACRES:

NA.51

PubChem Substance ID:

57651277

UNSPSC Code:

41106305

EC Number:

252-847-2

MDL number:

MFCD00149227

Beilstein/REAXYS Number:

4113439

Assay:

≥90% (HPLC)

Form:

powder

Solubility:

water: 50 mg/mL, clear, colorless

Storage temp.:

−20°C

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Product Name

Guanosine 5′-triphosphate sodium salt hydrate, ≥90% (HPLC)

Quality Level

100

assay

≥90% (HPLC)

form

powder

optical activity

[α]20/D −24±2°, c = 1% in 0.5 M Na₂HPO₄

impurities

≤3 mol/mol water (NMR)

solubility

water: 50 mg/mL, clear, colorless

shipped in

wet ice

storage temp.

−20°C

SMILES string

O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1

InChI key

HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

Related Categories

Biochemicals

Chemistry & Biochemicals

Nucleosides and Nucleotides

Phosphates

General description

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:

as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
in a solution for channel current recording in cell lines using a voltage-clamp technique.
to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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Evidence for Mechanosensitive Channel Activity of Tentonin 3/TMEM150C.

Gyu-Sang Hong et al.

Neuron, 94(2), 271-273 (2017-04-21)

Mechanosensation is essential for various physiological processes, and it is mediated by mechanotransduction channels. Recently, we reported that TMEM150C/Tentonin 3 (TTN3) confers mechanically activated currents with slow inactivation kinetics in several cell types, including dorsal root ganglion neurons (Hong et al.

The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.

Lukas Jakob Neukomm et al.

Development (Cambridge, England), 138(10), 2003-2014 (2011-04-15)

Multicellular organisms use programmed cell death to eliminate unwanted or potentially harmful cells. Improper cell corpse removal can lead to autoimmune diseases. The development of interventional therapies that increase engulfment activity could represent an attractive approach to treat such diseases.

Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase.

Fu-Jung Chang et al.

The Journal of biological chemistry, 280(12), 11513-11519 (2005-01-15)

The mechanism of desensitization of the nitric oxide (NO) receptor (alpha1.beta1 isoform of soluble guanylyl cyclase, sGC) is not known. Models of the structure of alpha1.beta1, based on the x-ray crystal structure of adenylyl cyclase (AC) suggest the existence of

Phosphorylation and nucleotide-dependent dephosphorylation of hepatic polypeptides related to the plasma cell differentiation antigen PC-1.

M Uriarte et al.

The Biochemical journal, 293 ( Pt 1), 93-100 (1993-07-01)

A glycoprotein fraction was isolated from rat liver membranes by affinity chromatography on immobilized wheat-germ lectin. Incubation of this fraction with MgATP or MgGTP resulted in a sequential phosphorylation and dephosphorylation of a complex of three polypeptides (118, 128 and

Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends.

S A Endow et al.

The EMBO journal, 13(11), 2708-2713 (1994-06-01)

Mutants of the yeast Kar3 protein are defective in nuclear fusion, or karyogamy, during mating and show slow mitotic growth, indicating a requirement for the protein both during mating and in mitosis. DNA sequence analysis predicts that Kar3 is a

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Global Trade Item Number

SKU	GTIN
51120-1G	04061826661116
51120-100MG	04061832491165
51120-25MG	04061832491189

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