51290
Hemoglobin from bovine blood
lyophilized, 2×cryst., ≥90% (SDS-PAGE), powder
Synonym(s):
Bovine hemoglobin, Hb, Methemoglobin
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About This Item
Form:
powder
Assay:
≥90% (SDS-PAGE)
Biological source:
bovine blood
Mol wt:
Mr ~64500
biological source
bovine blood
assay
≥90% (SDS-PAGE)
form
powder
quality
2×cryst., lyophilized
mol wt
Mr ~64500
technique(s)
UV/Vis spectroscopy: suitable
impurities
salt, none detected, ~0.3% Fe
loss
≤8% loss on drying
Quality Level
Gene Information
storage temp.
2-8°C
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General description
Hemoglobin (Hb) is the protein responsible for storage and transport of oxygen and other gaseous ligands in red blood cells (RBC). Hb is also the pioneer material for synthesis of Hb-based oxygen carriers (HBOCs) that can be used as substitutes for RBC.
Application
The solubility of α-elastin has been applied to construction of elastin-mimetic biomaterials.
Biochem/physiol Actions
Oxygen transporter, NO scavenger
Oxygen transporter. The Fe2+/Fe3+ balance is a physiological indicator of blood oxygenation; deoxygenated hemoglobin accessorizes a feedback loop by reducing nitrite to NO, a vasodilator which enhances blood flow to oxygen-deprived tissues.
Other Notes
Review: Oxygen carrier proteins
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Disclaimer
Since native hemoglobin is readily oxidized in air, these preparations may be predominantly methemoglobin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Paul W Buehler et al.
Biomaterials, 31(13), 3723-3735 (2010-02-13)
Hemoglobin-based oxygen carriers (HBOC) are currently being developed as red blood cell (RBC) substitutes for use in transfusion medicine. Despite significant commercial development, late stage clinical results of polymerized hemoglobin (PolyHb) solutions hamper development. We synthesized two types of PolyHbs
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