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Merck
CN

58756

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine

≥98.0% (HPLC)

Synonym(s):

1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
84477-73-6
Molecular Weight:
291.37
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
57651659
MDL number:
MFCD00132900
Beilstein/REAXYS Number:
5445506

Key Documents

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Product Name

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine, ≥98.0% (HPLC)

InChI

1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3

SMILES string

CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23

InChI key

QGSCXAWTTISKLF-UHFFFAOYSA-N

assay

≥98.0% (HPLC)

form

powder

storage temp.

2-8°C

Quality Level

100

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Related Categories

Biochem/physiol Actions

Less potent inhibitor of protein kinaseC than H-7

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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V Ladeda et al.
Experimental cell research, 242(2), 515-527 (1998-07-31)
The cell surface glycoprotein CD44 is proposed as a main participant in cell adhesion and migration. We studied the function, expression, and distribution of CD44 in the invasive and metastatic F3II murine carcinoma cell line during adhesion, spreading, migration, and
A Symes et al.
The Journal of biological chemistry, 272(15), 9648-9654 (1997-04-11)
Ciliary neurotrophic factor (CNTF)-dependent induction of expression of the neuropeptide vasoactive intestinal peptide (VIP) gene is mediated by a 180-base pair cytokine response element (CyRE) in the VIP promoter. To elucidate the molecular mechanisms mediating the transcriptional activation by CNTF
T Miyashita et al.
Receptors & channels, 7(2), 77-91 (2000-08-22)
We previously reported that the metabotropic glutamate receptor R1alpha (mGluR1alpha) can be activated not only by applying glutamate but also by raising extracellular Ca2+ (Ca2+o) concentration, and that the constant stimulation by Ca2+o causes morphological change of transfected Chinese Hamster
Mei-Hua Li et al.
Zhonghua er bi yan hou ke za zhi, 39(6), 353-355 (2004-10-08)
To study the influence of the inhibitor of protein kinase C (PKC), Iso-H7 [1-(5-lsoquinolinyl-sulfony)-3-methylpiperazine dihydrochloride] on eosinophil apoptosis in nasal polyp tissues. Nasal polyp tissues were cultured and divided into two groups, test group (with Iso-H7 in different concentration) and
J Kreuzer et al.
Journal of molecular medicine (Berlin, Germany), 74(3), 161-165 (1996-03-01)
The accumulation of blood monocytes at sites of predilection of the vessel wall is an early cellular event of atherogenesis. Proteins of the vessel wall may facilitate monocyte adhesion and thus promote their recruitment. It has been shown that the
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