Key Documents

View All Documentation

61962

Betaine

Name: Betaine
Brand: SIGMA

BioUltra, ≥99.0% (NT)

Synonym(s):

(Carboxymethyl)trimethylammonium inner salt, Oxyneurine, Trimethylglycine

Select a Size

Change View

About This Item

Linear Formula:

(CH₃)₃N⁺CH₂COO^-

CAS Number:

107-43-7

Molecular Weight:

117.15

UNSPSC Code:

41116107

NACRES:

NA.25

PubChem Substance ID:

57651874

EC Number:

203-490-6

Beilstein/REAXYS Number:

3537113

MDL number:

MFCD00012123

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

product line

BioUltra

Quality Level

200

assay

≥99.0% (NT)

impurities

insoluble matters, passes filter test

solubility

methanol: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl^-): ≤200 mg/kg, sulfate (SO₄^2-): ≤200 mg/kg

cation traces

Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤100 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg, Ca: ≤20 mg/kg

absorption

≤0.05 at 280 nm in methanol at 1 M, ≤0.09 at 260 nm in methanol at 1 M

SMILES string

C[N+](C)(C)CC([O-])=O

InChI

1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3

InChI key

KWIUHFFTVRNATP-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Biochemicals

Bioprocessing & Formulation Raw Materials

High-Purity Biochemicals and Reagents

Pharma & Biopharma Manufacturing

Upstream Process Chemicals

General description

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.

Application

Betaine has been used in reverse transcription to increase the thermal stability of proteins and to destabilize the DNA helix.

Biochem/physiol Actions

End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.

Betaine has been shown to increase S-adenosylmethionine (SAM) levels and hence, may have a role in diminishing hepatic steatosis. It is an osmolyte which protects cells against environmental stress.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Full-length RNA-seq from single cells using Smart-seq2.

Picelli S

Nature Protocols, 9(1), 171-181 (2014)

Multiple Independent Origins of Apicomplexan-Like Parasites.

Varsha Mathur et al.

Current biology : CB, 29(17), 2936-2941 (2019-08-20)

The apicomplexans are a group of obligate animal pathogens that include Plasmodium (malaria), Toxoplasma (toxoplasmosis), and Cryptosporidium (cryptosporidiosis) [1]. They are an extremely diverse and specious group but are nevertheless united by a distinctive suite of cytoskeletal and secretory structures related to

Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development.

Shangli Cheng et al.

Cell reports, 26(10), 2593-2607 (2019-03-07)

Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency, accompanied by dynamic changes in X chromosome activity in females. To investigate the molecular attributes of this process, we performed single-cell RNA-seq analysis of 1,724 cells of

Betaine in human nutrition.

Stuart A S Craig

The American journal of clinical nutrition, 80(3), 539-549 (2004-08-24)

Betaine is distributed widely in animals, plants, and microorganisms, and rich dietary sources include seafood, especially marine invertebrates ( approximately 1%); wheat germ or bran ( approximately 1%); and spinach ( approximately 0.7%). The principal physiologic role of betaine is

Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.

Bernd C Schwahn et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 17(3), 512-514 (2003-01-29)

Hyperhomocysteinemia, a proposed risk factor for cardiovascular disease, is also observed in other common disorders. The most frequent genetic cause of hyperhomocysteinemia is a mutated methylenetetrahydrofolate reductase (MTHFR), predominantly when folate status is impaired. MTHFR synthesizes a major methyl donor

View All Related Papers

Global Trade Item Number

SKU	GTIN
61962-250G	04061832701080
61962-50G	04061832701097

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service