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63493

Hoechst 34580

Name: Hoechst 34580
Brand: SIGMA

Trihydrochloride salt, ≥98.0% (HPLC)

Synonym(s):

N,N-Dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5′-bi-1H-benzimidazol]-2′-yl]benzenamine trihydrochloride, HOE 34580

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₉N₇ · 3HCl

CAS Number:

911004-45-0

Molecular Weight:

560.95

MDL number:

MFCD29073033

UNSPSC Code:

12352108

PubChem Substance ID:

329759866

NACRES:

NA.32

Assay:

≥98.0% (HPLC)

Solubility:

H₂O: 1 mg/mL, clear, slightly yellow to deep greenish-yellow

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Properties

Quality Level

100

assay

≥98.0% (HPLC)

quality

Trihydrochloride salt

solubility

H₂O: 1 mg/mL, clear, slightly yellow to deep greenish-yellow

fluorescence

λ_ex 357 nm; λ_em 490 nm±10 nm in H₂O (free dye)

storage temp.

−20°C

SMILES string

Cl.Cl.Cl.CN1CCN(CC1)c2ccc3nc([nH]c3c2)-c4ccc5nc([nH]c5c4)-c6ccc(cc6)N(C)C

InChI

1S/C27H29N7.3ClH/c1-32(2)20-7-4-18(5-8-20)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-9-21(17-25(23)31-27)34-14-12-33(3)13-15-34;;;/h4-11,16-17H,12-15H2,1-3H3,(H,28,30)(H,29,31);3*1H

InChI key

IPMZLKUUQSFUTA-UHFFFAOYSA-N

Description

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Stem cell exosomes inhibit angiogenesis and tumor growth of oral squamous cell carcinoma.

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Scientific reports, 9(1), 663-663 (2019-01-27)

Recently, exosomes secreted by menstrual mesenchymal stem cells have been identified as inhibitory agents of tumor angiogenesis and modulators of the tumor cell secretome in prostate and breast cancer. However, their direct effect on endothelial cells and paracrine mediators have

P300/CBP Associated Factor (PCAF) Deficiency Enhances Diet-Induced Atherosclerosis in ApoE3*Leiden Mice via Systemic Inhibition of Regulatory T Cells.

Alwin de Jong et al.

Frontiers in cardiovascular medicine, 7, 604821-604821 (2021-02-16)

Background: Inflammatory stimuli induced by NF-kB drive atherosclerotic lesion formation. The epigenetic P300/CBP associated factor (PCAF) post-transcriptionally acetylates FoxP3, which is required for regulatory T-cell (Treg) differentiation and immune modulation. We hypothesize that PCAF deficiency affects atherosclerosis via regulation of

Mapping metabolic oscillations during cell cycle progression.

Irena Roci et al.

Cell cycle (Georgetown, Tex.), 19(20), 2676-2684 (2020-10-06)

Proliferating cells must synthesize a wide variety of macromolecules while progressing through the cell cycle, but the coordination between cell cycle progression and cellular metabolism is still poorly understood. To identify metabolic processes that oscillate over the cell cycle, we

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Global Trade Item Number

SKU	GTIN
63493-5MG	04061833646588