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Merck
CN

67578

Dextran sulfate sodium salt

Synonym(s):

Dextran Sulfate Sodium

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352201
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form

powder

Quality Level

loss

≤10% loss on drying

useful pH range

6.0-8.0 (10 g/L)

solubility

H2O: 100 mg/mL, colorless to faintly greenish-yellow

storage temp.

room temp

General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
Dextran sulfate is used as a diluent in in situ hybridization experiments to increase hybridization of probes to target sequences in tissues.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.


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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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The rate of nucleic acid annealing to cytological preparations is increased in the presence of dextran sulfate.
L L Lederman et al.
Analytical biochemistry, 117(1), 158-163 (1981-10-01)
Sinah-Sophia Weiterer et al.
The EMBO journal, 39(1), e101533-e101533 (2019-11-09)
How cytokine-driven changes in chromatin topology are converted into gene regulatory circuits during inflammation still remains unclear. Here, we show that interleukin (IL)-1α induces acute and widespread changes in chromatin accessibility via the TAK1 kinase and NF-κB at regions that
Nadezhda V Petrova et al.
Cell cycle (Georgetown, Tex.), 15(3), 337-344 (2015-12-23)
Heat stress is one of the best-studied exogenous stress factors; however little is known about its delayed effects. Recently, we have shown that heat stress induces cellular senescence-like G2 arrest exclusively in early S-phase cells. The mechanism of this arrest



Global Trade Item Number

SKUGTIN
67578-5G04061832742168
67578-100G04061832736167
67578-25G04061832742069