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68059

FITC-CM-Dextran

average mol wt 4,000

Synonym(s):

FITC-CM-Dextran 4, Fluorescein isothiocyanate–Carboxymethyl–Dextran, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352116
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biological source

synthetic

Quality Level

100

conjugate

FITC conjugate

form

powder or crystals

mol wt

average mol wt 4,000

composition

carboxymethyl content, 3-7%

extent of labeling

0.001-0.020 mol/mol FITC glucose

technique(s)

permeability assay: suitable

color

light orange to dark orange, orange-yellow, light yellow to dark yellow, yellow-orange

fluorescence

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

General description

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Application

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP3806
BCCN9621
BCCN3103
BCCM3761
BCCL2895

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Articles

FITC-labelled polysaccharides

Explore FITC-labelled polysaccharides and their properties, including impact of molecular weight on molecule dimensions.

FITC标记多糖

包括FITC-葡聚糖、FITC-DEAE-葡聚糖(FDD)、FITC-羧甲基 - 葡聚糖（FCM-葡聚糖）在内的FITC标记多糖的补充信息。本页面主要介绍了重均分子量对于对应分子尺寸和其他物理性质的影响

Yuxin Leng et al.
PloS one, 9(10), e109350-e109350 (2014-10-09)
Intra-abdominal hypertension (IAH) is known as a common, serious complication in critically ill patients. Bacterial translocation and permeability changes are considered the pathophysiological bases for IAH-induced enterogenic endotoxemia and subsequent multiorgan failure. Nevertheless, the effects of slightly elevated intra-abdominal pressures
Stefanie J Anderson et al.
Comparative medicine, 69(1), 4-15 (2018-12-14)
Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycin and metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function, cytokine and chemokine profiles, and neutrophil migration in
Yuxin Leng et al.
Scientific reports, 6, 22814-22814 (2016-03-17)
Intra-abdominal hypertension (IAH) is a common and serious complication in critically ill patients for which there is no well-defined treatment strategy. Here, we explored the effect of IAH on multiple intestinal barriers and discussed whether the alteration in microflora provides
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Global Trade Item Number

SKUGTIN
68059-1G04061826643563