69453
L-Homocysteine
≥98.0% (NT)
Synonym(s):
(S)-2-Amino-4-mercaptobutyric acid
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About This Item
Linear Formula:
HSCH2CH2CH(NH2)COOH
CAS Number:
Molecular Weight:
135.18
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
227-891-0
MDL number:
Product Name
L-Homocysteine, ≥98.0% (NT)
InChI
1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1
InChI key
FFFHZYDWPBMWHY-VKHMYHEASA-N
SMILES string
N[C@@H](CCS)C(O)=O
assay
≥98.0% (NT)
form
powder
optical activity
[α]/D 25.5±1.5°, c = 1 in 1 M HCl
color
white
mp
263-265 °C
application(s)
cell analysis
relevant disease(s)
Alzheimer′s disease
storage temp.
−20°C
Quality Level
Application
L-homocysteine has been used as a supplement in cell culture media.
Biochem/physiol Actions
Elevated homocysteine levels in plasma and tissue are associated with brain atrophy in Alzheimer′s disease as well as in healthy eldery subjects. Increased homocysteine is due to deficiencies in vitamin B status, specifically folate, B6 and B12 vitamins, which act as cofactors for enzymes involved in homocysteine metabolism.
General description
L-homocysteine is used to diagnose homocystinuria.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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Li Ma et al.
Nature communications, 11(1), 2772-2772 (2020-06-04)
Vestigial structures are key indicators of evolutionary descent, but the mechanisms underlying their development are poorly understood. This study examines vestigial eye formation in the teleost Astyanax mexicanus, which consists of a sighted surface-dwelling morph and multiple populations of blind
Babak Hooshmand et al.
Brain : a journal of neurology, 136(Pt 9), 2707-2716 (2013-08-29)
Elevated plasma total homocysteine is associated with increased risk of dementia/Alzheimer's disease, but underlying pathophysiological mechanisms are not fully understood. This study investigated possible links between baseline homocysteine, and post-mortem neuropathological and magnetic resonance imaging findings up to 10 years
Gwenaëlle Douaud et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9523-9528 (2013-05-22)
Is it possible to prevent atrophy of key brain regions related to cognitive decline and Alzheimer's disease (AD)? One approach is to modify nongenetic risk factors, for instance by lowering elevated plasma homocysteine using B vitamins. In an initial, randomized
Jhonatan A Hernandez-Valdes et al.
Nature communications, 11(1), 1203-1203 (2020-03-07)
Auxotrophy, the inability to produce an organic compound essential for growth, is widespread among bacteria. Auxotrophic bacteria rely on transporters to acquire these compounds from their environment. Here, we study the expression of both low- and high-affinity transporters of the
Sanne Visser et al.
American journal of obstetrics and gynecology, 211(4), 373-373 (2014-03-19)
The aim of this study was to investigate which nonclassic cardiovascular biomarkers are associated with persistent endothelial dysfunction after pregnancy in women with a history of hypertensive pregnancy disorders compared with women with uncomplicated pregnancies. This was a systematic review
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