69579
γ,γ-Dimethylallyl pyrophosphate ammonium salt
≥93.0% (TLC)
Synonym(s):
3-Methyl-2-butenyl pyrophosphate ammonium salt, DMAPP, Prenyl pyrophosphate ammonium salt
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About This Item
Empirical Formula (Hill Notation):
C5H12O7P2 · xNH3
CAS Number:
Molecular Weight:
246.09 (free acid basis)
UNSPSC Code:
12352205
NACRES:
NA.25
Assay:
≥93.0% (TLC)
Form:
powder
Assay
≥93.0% (TLC)
form
powder
storage temp.
−20°C
SMILES string
N.C\C(C)=C\COP(O)(=O)OP(O)(O)=O
InChI
1S/C5H12O7P2.H3N/c1-5(2)3-4-11-14(9,10)12-13(6,7)8;/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8);1H3
InChI key
DPJANMSJRVSJKR-UHFFFAOYSA-N
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Application
Prenyl pyrophosphate, an intermediate in mevalonic acid pathway isoprenoid/terpene biosynthesis, is use to study the kinetics of farnesyl pyrophosphate synthases.
Biochem/physiol Actions
Intermediate in terpene biosynthesis
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Anuradha Srivastava et al.
Infectious disorders drug targets, 8(1), 16-30 (2008-05-14)
Synthesis of farnesyl pyrophosphate (FPP), a key intermediate of the isoprenoid biosynthesis pathway, is catalyzed by FPP synthase (FPPS). Antiprotozoal properties of bisphosphonates, which target FPPS, have generated interest in FPPS as a potential antiprotozoal drug target. The genes encoding
Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development.
Dhar MK, Koul A, Kaul S.
New Biotechnology (2012)
Shuting Sun et al.
Expert opinion on therapeutic patents, 21(9), 1433-1451 (2011-06-28)
Farnesyl pyrophosphate synthase (FPPS, also known as farnesyl diphosphate synthase (FDPS)) is one of the key enzymes involved in the mevalonate pathway and as such is widely expressed. FPPS modulators, specifically FPPS inhibitors, are useful in treating a number of
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