73156
N-Methyl-L-serine
≥98% (TLC)
Synonym(s):
(S)-3-Hydroxy-2-(methylamino)propionic acid, N-Me-Ser-OH
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C4H9NO3
CAS Number:
Molecular Weight:
119.12
UNSPSC Code:
12352202
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2498641
Product Name
N-Methyl-L-serine, ≥98% (TLC)
InChI
1S/C4H9NO3/c1-5-3(2-6)4(7)8/h3,5-6H,2H2,1H3,(H,7,8)/t3-/m0/s1
SMILES string
CN[C@@H](CO)C(O)=O
InChI key
PSFABYLDRXJYID-VKHMYHEASA-N
assay
≥98% (TLC)
form
powder
optical activity
[α]/D +9.5±1.0°, c = 1 in 1 M HCl
composition
carbon, 39.5-41.1%
nitrogen, 11.5-12.0%
color
white
mp
204 °C
Quality Level
Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue. N-Methyl-L-serine stimulates hyaluronan production in human skin fibroblasts.
N-Methyl-L-serine has been found to stimulate production of high molecular mass hyaluronan in human fibroblasts. This effect was specific to methylated L-serine and not observed with other methylated amino acids.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
N-Methyl-L-serine stimulates hyaluronan production in human skin fibroblasts.
Sakai, S., et al.
Skin Pharmacology and Physiology, 12, 276-283 (1999)
Péter Nemes et al.
Journal of mass spectrometry : JMS, 40(1), 43-49 (2004-12-08)
The association properties of natural and non-natural amino acids were studied in detail using electrospray ionization mass spectrometry. The results show a highly diverse cluster formation behavior of amino acids. There are differences regarding the degree of clustering (average cluster
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service