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Merck
CN

75250

Salvinorin B

≥93.0% (HPLC), κ-opioid DREADD activator, powder or crystals

Synonym(s):

(2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo 2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester, Divinorin B

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About This Item

Empirical Formula (Hill Notation):
C21H26O7
CAS Number:
92545-30-7
Molecular Weight:
390.43
NACRES:
NA.83
PubChem Substance ID:
329766282
UNSPSC Code:
12352204
MDL number:
MFCD16036232
Beilstein/REAXYS Number:
4335292

Key Documents

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Product Name

Salvinorin B, ≥93.0% (HPLC)

InChI key

BLTMVAIOAAGYAR-CEFSSPBYSA-N

SMILES string

COC(=O)[C@@H]1C[C@H](O)C(=O)[C@H]2[C@@]1(C)CC[C@H]3C(=O)O[C@@H](C[C@]23C)c4ccoc4

InChI

1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1

assay

≥93.0% (HPLC)

form

powder or crystals

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

solubility

chloroform: soluble

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Salvinorin B is the major deacetylated metabolite of salvinorin A, a diterpene from Salvia divinorum with reported psychotropic activity, not observed in Salvinorin B.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP0659
BCCK2957
BCCJ1070
BCCD5112
BCCB1922

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Seda Damla Hatipoglu et al.
Phytochemical analysis : PCA, 28(6), 541-549 (2017-07-20)
Salvia, an important and widely available member of Lamiaceae family. Although comparative analysis on secondary metabolites in several Salvia species from Turkey has been reported, their hallucinogenic chemicals have not been screened thoroughly. This study provides LC-MS/MS analysis of 40
Kenji Tsujikawa et al.
Forensic science international, 180(2-3), 105-109 (2008-09-05)
Two major salvinorins, salvinorin A (SalA) and salvinorin B (SalB), in three Salvia divinorum dried leaf products and nine of its "concentrated extract" products circulated in Japan were determined. These ingredients were extracted twice with acetonitrile and decolored with graphite
Thomas A Munro et al.
Bioorganic & medicinal chemistry, 16(3), 1279-1286 (2007-11-06)
Protection of salvinorin B as standard alkoxyalkyl ethers yielded highly potent kappa opioid receptor agonists. Ethoxymethyl ether 6 is among the most potent and selective kappa agonists reported to date. Fluoroethoxymethyl ether 11 is the first potent, selective fluorinated kappa
Mark S Schmidt et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 818(2), 221-225 (2005-03-01)
Salvinorin A was quantitated in human and rhesus monkey plasma, rhesus monkey cerebrospinal fluid, and human urine by negative ion LC-MS/APCI. The method for Salvinorin A has been fully validated, the LLOQ using FDA guidelines is 2 ng/mL for 0.5
Kai Yu et al.
Nature neuroscience, 20(12), 1680-1685 (2017-12-01)
Experience-driven synaptic plasticity in the lateral amygdala is thought to underlie the formation of associations between sensory stimuli and an ensuing threat. However, how the central amygdala participates in such a learning process remains unclear. Here we show that PKC-δ-expressing
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