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Sodium dodecyl sulfate

Name: Sodium dodecyl sulfate
Brand: SIGMA

≥99.0% (GC), dust-free pellets

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Synonym(s):

Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt, SDS, Sodium lauryl sulfate

Linear Formula:

CH₃(CH₂)₁₁OSO₃Na

CAS Number:

151-21-3

Molecular Weight:

288.38

Beilstein:

3599286

EC Number:

205-788-1

MDL number:

MFCD00036175

eCl@ss:

39093306

PubChem Substance ID:

329766677

NACRES:

NA.25

description

anionic

Quality Level

200

Assay

≥99.0% (GC)

form

rod

mol wt

average mol wt 18,000

aggregation number

loss

≤5% loss on drying

CMC

7-10 (lit.)

mp

204 - 207 °C (399 - 405 °F)
204-207 °C (lit.)

transition temp

cloud point >100 °C(lit.)

solubility

H₂O: soluble 0.29 gm in 10ml, clear, colorless
H₂O: 0.1 M at 20 °C, clear, colorless
130 g/L at 20 °C (68 °F)

density

1 g/cm³

anion traces

chloride (Cl^-): ≤200 mg/kg

cation traces

Ca: ≤25 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤200 mg/kg
Mg: ≤20 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

HLB

40(lit.)

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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Related Categories

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

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General description

Sodium dodecyl sulfate (SDS) is an organic sodium salt used as both a detergent and a protein denaturant in biochemical research. Its unique structure includes a long-chain aliphatic group with a negatively charged sulfate, making it an effective agent for denaturing proteins. This property is especially valuable in electrophoresis, a technique used to separate and analyze macromolecules like proteins. SDS, with its negative charge, interacts with proteins and lipids to create micellar structures, aiding in solubilizing and stabilizing these biomolecules.

Application

Sodium dodecyl sulfate (SDS) has been used:

as a negatively charged surfactant to study its effects on filtration flux and membrane fouling during the microfiltration of the surfactant-stabilized oil emulsion
as a component of plant extraction buffer, and transferring buffer for western blot
as a component of 5× Laemmli sample buffer (5× LB) and 10× SDS running buffer for sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblot

Anionic detergent

Biochem/physiol Actions

Sodium dodecyl sulfate (SDS) effectively binds to the positively charged and the hydrophobic residues of proteins via sulfate groups and alkyl chains. It functions as a vital detergent in the domain of structural biology and protein folding/unfolding studies. SDS can stimulate the creation of α-helices in a protein structure. It has the ability to promote cooperative unfolding in several proteins including bovine serum albumin (BSA), β-lactoglobulin, α-lactalbumin, and hen egg-white lysozyme structures at elevated concentrations.

Features and Benefits

Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications
Tested for trace levels of Anions and Cations
High-purity product ideal for biochemical research purposes

Other Notes

For additional information on our range of Biochemicals, please complete this form.

comparable product

Product No.

Description

Pricing

Signal Word

Danger

Hazard Statements

H302 - H315 - H318 - H412

Precautionary Statements

P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

338.0 °F

Flash Point(C)

170 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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J Kamerbeek et al.

Journal of clinical microbiology, 35(4), 907-914 (1997-04-01)

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A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.

D Wessel et al.

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Freeze-fracture replica electron microscopy combined with SDS digestion for cytochemical labeling of integral membrane proteins. Application to the immunogold labeling of intercellular junctional complexes.

K Fujimoto

Journal of cell science, 108 ( Pt 11), 3443-3449 (1995-11-01)

We propose a new electron microscopic method, the sodium dodecylsulphate (SDS)-digested freeze-fracture replica labeling technique, to study the two-dimensional distribution of integral membrane proteins in cellular membranes. Unfixed tissue slices were frozen with liquid helium, freeze-fractured, and replicated in a

The gross conformation of protein-sodium dodecyl sulfate complexes.

J A Reynolds et al.

The Journal of biological chemistry, 245(19), 5161-5165 (1970-10-10)

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