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76157

(4R)-4-Hydroxy-L-glutamic acid

≥98.0% (TLC)

Synonym(s):

erythro-(4R)-4-Hydroxy-L-glutamic acid, H-(2S,4R)-γ-Hydroxy-Glu-OH

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About This Item

Empirical Formula (Hill Notation):
C5H9NO5
CAS Number:
2485-33-8
Molecular Weight:
163.13
NACRES:
NA.28
PubChem Substance ID:
329766558
UNSPSC Code:
12352202
MDL number:
MFCD00672375
Beilstein/REAXYS Number:
1725871
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Product Name

(4R)-4-Hydroxy-L-glutamic acid, ≥98.0% (TLC)

Quality Segment

100

assay

≥98.0% (TLC)

form

powder

optical activity

[α]/D 20.5±1.5°, c = 1 in H2O

color

white

mp

171 °C

storage temp.

−20°C

SMILES string

N[C@@H](C[C@@H](O)C(O)=O)C(O)=O

InChI

1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1

InChI key

HBDWQSHEVMSFGY-STHAYSLISA-N

Biochem/physiol Actions

(4R)-4-Hydroxy-L-glutamic acid or (2S,4R)-4-hydroxyglutamate was shown to activate the metabotropic glutamate receptors, mGlu1a, mGlu2, and mGlu8a in a dose-dependent manner.
Substrate for aminotransferase; pharmacological characterization at human glutamate transporter subtypes 1-3; for studying structure-activity relationships (SAR) for ionotropic and metabotropic glutamate receptors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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