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PBFI-AM

Name: PBFI-AM
Brand: SIGMA

suitable for fluorescence, ≥98.0% (HPCE)

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Synonym(s):

Potassium indicator PBFI-AM, Potassium-binding benzofuran isophthalate-AM

Empirical Formula (Hill Notation):

C₅₈H₆₂N₂O₂₄

CAS Number:

124549-23-1

Molecular Weight:

1171.11

MDL number:

MFCD00083475

PubChem Substance ID:

57652631

NACRES:

NA.32

Assay

≥98.0% (HPCE)

form

powder

solubility

DMSO: soluble
methanol: soluble

fluorescence

λ_ex 334 nm; λ_em 525 nm (with Na)
λ_ex 370 nm; λ_em 540 nm in methanol

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

COc1cc2cc(oc2cc1N3CCOCCOCCN(CCOCCOCC3)c4cc5oc(cc5cc4OC)-c6ccc(cc6C(=O)OCOC(C)=O)C(=O)OCOC(C)=O)-c7ccc(cc7C(=O)OCOC(C)=O)C(=O)OCOC(C)=O

InChI

1S/C58H62N2O24/c1-35(61)75-31-79-55(65)39-7-9-43(45(23-39)57(67)81-33-77-37(3)63)51-25-41-27-53(69-5)47(29-49(41)83-51)59-11-15-71-19-21-73-17-13-60(14-18-74-22-20-72-16-12-59)48-30-50-42(28-54(48)70-6)26-52(84-50)44-10-8-40(56(66)80-32-76-36(2)62)24-46(44)58(68)82-34-78-38(4)64/h7-10,23-30H,11-22,31-34H2,1-6H3

InChI key

AUKRBWNSOWVABU-UHFFFAOYSA-N

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Application

suitable for the detection of K⁺

Other Notes

Cell permeant deriv. of fluorescent indicator for mitochondrial potassium

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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4-aminopyridine decreases progesterone production by porcine granulosa cells.

Yan Li et al.

Reproductive biology and endocrinology : RB&E, 1, 31-31 (2003-05-13)

Ion channels occur as large families of related genes with cell-specific expression patterns. Granulosa cells have been shown to express voltage-gated potassium channels from more than one family. The purpose of this study was to determine the effects of 4-aminopyridine

Acid-sensing ion channel 1a contributes to the effect of extracellular acidosis on NLRP1 inflammasome activation in cortical neurons.

Yu-Chan Wang et al.

Journal of neuroinflammation, 12, 246-246 (2015-12-31)

Acid-sensing ion channels (ASICs) are cation channels which were activated by extracellular acidosis and involved in various physiological and pathological processes in the nervous system. Inflammasome is a key component of the innate immune response in host against harmful and

P. Jezek et al.

The Journal of Biological Chemistry, 264, 10522-10522 (1990)

Mitochondrial K+ as modulator of Ca(2+)-dependent cytotoxicity in hepatocytes. Novel application of the K(+)-sensitive dye PBFI (K(+)-binding benzofuran isophthalate) to assess free mitochondrial K+ concentrations.

J P Zoeteweij et al.

The Biochemical journal, 299 ( Pt 2), 539-543 (1994-04-15)

In isolated rat hepatocytes a sustained high increase in intracellular free Ca2+ ([Ca2+]i), induced by extracellular ATP, is associated with mitochondrial dysfunction and cell death. The Ca(2+)-induced effects are Pi-dependent and less severe when the intracellular K+ content is low.

Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.

Tongguang Wang et al.

PloS one, 7(8), e43950-e43950 (2012-09-07)

Increasing evidence supports a critical role of T cells in neurodegeneration associated with acute and subacute brain inflammatory disorders. Granzyme B (GrB), released by activated T cells, is a cytotoxic proteinase which may induce perforin-independent neurotoxicity. Here, we studied the

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