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78825

Liquiritigenin

≥97.0% (HPLC)

Synonym(s):

7,4′-Dihydroxyflavanone, 7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one

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About This Item

Empirical Formula (Hill Notation):
C15H12O4
CAS Number:
578-86-9
Molecular Weight:
256.25
UNSPSC Code:
12352202
NACRES:
NA.28
PubChem Substance ID:
329768184
MDL number:
MFCD00287289
Beilstein/REAXYS Number:
359378
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Quality Segment

100

assay

≥97.0% (HPLC)

form

powder or crystals

impurities

≤7% water

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

SMILES string

Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2

InChI

1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1

InChI key

FURUXTVZLHCCNA-AWEZNQCLSA-N

General description

Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.

Application

Liquiritigenin has been used:
  • to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer
  • as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract
  • as a potential antiviral drug against hepatitis C virus (HCV) infection

Biochem/physiol Actions

Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components. It is a selective estrogen receptor β agonist cells. Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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