81349
Poly(2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt
powder
Synonym(s):
Poly(dI-dC) sodium salt
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About This Item
Form:
powder
Solubility:
water: 1 mL/vial, clear, colorless
Storage temp.:
−20°C
Product Name
Poly(2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt, free from low molecular weight nucleotides, lyophilized
grade
Molecular Biology
Quality Segment
form
powder
quality
lyophilized
mol wt
Mr ~2.5 × 106 (broad molecular weight distribution), Mr ~2500000
packaging
ampule of ≥10 units A260
solubility
water: 1 mL/vial, clear, colorless
storage temp.
−20°C
General description
Poly (2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt is an alternating copolymer that acts as a substrate for DNA methyltransferases.
Application
Poly(2′-deoxyinosinic-2′-deoxycytidylic acid) sodium salt has been used in electrophoretic mobility shift assay (EMSA) of the transcription factor AP-2 Alpha (TFAP2A) and in southwestern blotting of human embryonic kidney cells (HEK293) nuclear extract.
Suitable for
- non-specific blocking agent in EMSA
- evaluation of DNA methyltransferases
- DNA-small molecule or drug interaction studies
Biochem/physiol Actions
Poly(2′-deoxyinosinic-2′-deoxycytidylic acid), poly(dI-dC) is a synthetic DNA substrate. At high salt, Poly(dI-dC) exists in left handed helical conformation and reverts to right-handed form upon decreasing salt. It is used as a non-specific competitor in electrophoretic mobility shift assay (EMSA).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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