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Merck
CN

82435

Puerarin

≥98.0% (HPLC)

Synonym(s):

8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, Kakonein

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About This Item

Empirical Formula (Hill Notation):
C21H20O9
CAS Number:
3681-99-0
Molecular Weight:
416.38
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
57652917
MDL number:
MFCD00076007
Beilstein/REAXYS Number:
64198

Key Documents

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InChI

1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)ccc3C(=O)C(=COc23)c4ccc(O)cc4

InChI key

HKEAFJYKMMKDOR-VPRICQMDSA-N

assay

≥98.0% (HPLC)

form

powder

Quality Level

100

Gene Information

mouse ... Aldh1a2(19378), Maoa(17161)

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Related Categories

Biochem/physiol Actions

Isoflavone component of kudzu. Reduces anxiety symptoms associated with alcohol withdrawal.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6041
BCCK6262
BCCJ0445
BCBZ8152
BCBR8847V

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David H Overstreet et al.
Pharmacology, biochemistry, and behavior, 75(3), 619-625 (2003-08-05)
Because extracts of kudzu have been used as a hangover remedy in China for many centuries, we tested the ability of NPI-031G (puerarin), an isoflavone isolated from kudzu, to counteract anxiogenic effects associated with withdrawal from chronic alcohol exposure. NPI-O31G
Lin Wang et al.
Human & experimental toxicology, 32(2), 172-185 (2013-01-15)
Puerarin (PU), a natural flavonoid, has been reported to possess anti-oxidative and anti-inflammatory activities. In the present study, female Sprague-Dawley rats received lead (Pb) nitrate (300 mg/L, via drinking water) and/or PU (400 mg/kg/day, orally) to investigate the protective effects of PU
E Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(1), 49-52 (2013-04-20)
To prepare membrane controlled tablets of puerarin sinclusion compound and to investigate the drug release in vitro. The single factors affecting drug release in vitro were investigated. Then, uniform design was used to optimize the formulation of controlled osmotic-pump tablets.
Feng Tian et al.
Neuroscience letters, 543, 64-68 (2013-04-11)
Puerarin extracted from radix puraeriae is shown to exert a variety of pharmacological effects including neuroprotective properties. However, its mechanisms of action are needed to further explore. The study was designed to investigate the mechanism of puerarin treatment of acute
Xiang-Yang Sun et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(6), 980-983 (2012-12-15)
To optimize the parameters of extraction technology for Puerarin from Pueraria lobata by Central Composite Design-Response Surface Methodology. Used the ratio of dosage liquid and extraction time as the examination factor,the content of puerarin for the extraction percentage as the
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