82934
7-Hydroxycitronellal
Odorant used in allergy studies
Synonym(s):
7-Hydroxy-3,7-dimethyloctanal, Citronellal hydrate
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C10H20O2
CAS Number:
Molecular Weight:
172.26
NACRES:
NA.52
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
203-518-7
MDL number:
InChI
1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3
InChI key
WPFVBOQKRVRMJB-UHFFFAOYSA-N
SMILES string
[H]C(CC(C)CCCC(O)(C)C)=O
grade
Molecular Biology
assay
≥95.0% (GC)
form
powder
density
0.92 g/mL at 20 °C (lit.)
storage temp.
room temp
Quality Level
General description
7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.
Application
Suitable for
- contact sensitization studies to identify allergens present in cosmetic preparations
- elucidation of molecular pathways related to allergic reactions
- analytical standard
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
B Kreilgård et al.
Journal of the American Academy of Dermatology, 21(4 Pt 2), 836-838 (1989-10-01)
The choice of vehicle for patch test materials is important for the bioavailability and stability of the allergens. Examples are given from the standardization of the TRUE Test and include caine mix, Kathon CG, and fragrance mix.
M Cluzel-Tailhardat et al.
Toxicology letters, 174(1-3), 98-109 (2007-10-16)
A critical step in the induction of allergic contact dermatitis is the interaction of haptens with immature dendritic cells (iDC) leading to their activation. Therefore iDC appear as suitable targets for the evaluation of the sensitizing properties of haptens with
S Sieben et al.
Toxicology and applied pharmacology, 172(3), 172-178 (2001-04-21)
Fragrances are worldwide a major cause of allergic contact dermatitis (ACD), a delayed-type hypersensitivity reaction mediated by T lymphocytes. We investigated T cell responses to fragrances using peripheral blood mononuclear cells (PBMC) and T cells from skin lesions of fragrance-allergic
Fabien Merckel et al.
Chemical research in toxicology, 23(9), 1433-1441 (2010-08-28)
In chemico methods, based on the assessment of hapten reactivity toward peptides, have been proposed as alternative methods for the assessment of the skin sensitizing potential of chemicals. However, even if these approaches seem very promising, a major drawback inherent
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service