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Sigma-Aldrich

Streptavidin from Streptomyces avidinii

affinity purified, lyophilized from 10 mM potassium phosphate, ≥13 U/mg protein

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CAS Number:
9013-20-1
MDL number:
MFCD00082035
NACRES:
NA.32

form

powder

Quality Level

200

quality

affinity purified
lyophilized from 10 mM potassium phosphate

specific activity

≥13 U/mg protein

mol wt

Mr ~60000

solubility

H2O: 1 mg/mL, clear to hazy, colorless to faintly yellow

storage temp.

−20°C

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General description

Streptavidin is a crystalline protein synthesized by Streptomycetes.

Application

Streptavidin from Streptomyces avidinii has been used:
  • in the pre-functionalization of self-propelled catalytic micromotors
  • in the fabrication and modification of hydroxyapatite-chitosan (HA-CTS) nanofilm-coated substrates
  • as an analyte to bind biomolecules to the gold-inverted polymer solar cells (Au-IPSC)

Biochem/physiol Actions

Streptavidin is a biotin binding protein and has the ability to bind four molecules of biotin. The biotin binding pocket of streptavidin helps to interact with biotin. It can be used to enhance protein binding and multimerization.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.
The sales quantitites 1 mg and 5 mg

Unit Definition

1 U corresponds to the amount of protein which binds 1μg (+)-biotin at pH 7.5

Analysis Note

Binding capability: Streptavidin binds one molecule of biotin per subunit. Comparison of biotin binding and absorbance measurements indicates that ≤5% binding sites are occupied.

Other Notes

Review: Application of the avidin-biotin technique in microbiology; Protein isolated from the bacterium Streptomyces avidinii, having a high affinity for biotin; Avidin-Biotin technology

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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D.A. Fuccillo
Biotechniques, 3, 494-494 (1985)
Soon Gang Choi et al.
Nature communications, 10(1), 3907-3907 (2019-08-31)
Complementary assays are required to comprehensively map complex biological entities such as genomes, proteomes and interactome networks. However, how various assays can be optimally combined to approach completeness while maintaining high precision often remains unclear. Here, we propose a framework
Scientific and Clinical Applications of Magnetic Carriers (2013)
Evolved streptavidin mutants reveal key role of loop residue in high-affinity binding
Magalhaes M L B, et al.
Protein Science, 20(7), 1145-1154 (2011)
Yuan-Yuan Chen et al.
Journal of Cancer, 7(1), 69-79 (2016-01-02)
Capture and identification of circulating tumor cells (CTCs) in the blood system can help guide therapy and predict the prognosis of cancer patients. However, simultaneous capture and identification of CTCs with both epithelial and mesenchymal phenotypes remains a formidable technical
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