Key Documents

View All Documentation

88185

Tetrazole solution

Name: Tetrazole solution
Brand: SIGMA

~0.45 M in acetonitrile, solution, suitable for DNA synthesis, filtered through a 1 μm filter

Synonym(s):

1H-Tetrazole

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

CH₂N₄

CAS Number:

288-94-8

Molecular Weight:

70.05

NACRES:

NA.21

PubChem Substance ID:

57653295

UNSPSC Code:

12352100

MDL number:

MFCD00005247

Beilstein/REAXYS Number:

105799

Technique(s):

DNA synthesis: suitable

Bp:

84 °C (lit.)

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

Tetrazole solution, suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

form

liquid

Quality Level

300

quality

filtered through a 1 μm filter

concentration

~0.45 M in acetonitrile

technique(s)

DNA synthesis: suitable

impurities

≤0.003% water

bp

84 °C (lit.)

mp

156-158 °C (lit.)

density

0.798 g/mL at 20 °C

SMILES string

c1nnn[nH]1

InChI

1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)

InChI key

KJUGUADJHNHALS-UHFFFAOYSA-N

Related Categories

Chemical Synthesis

Coupling Reagents and Nucleosides

General description

The product is ~0.45M solution of tetrazole in acetonitrile. Tetrazole ring plays significant role in various synthetic and industrial processes.

Application

Tetrazole solution is useful for DNA synthesis. It may be employed as a catalyst for the in situ synthesis of deoxyribonucleoside phosphoramidites. It may be used in the preparation of following anionic nucleotide-lipids:

thymidine 3′-(1,2-dilauroyl-sn-glycero-3-phosphate) , diC₁₂-3′-dT
thymidine 3′-(1,2-dimyristoyl-sn-glycero-3-phosphate) diC₁₄- 3′-dT
thymidine-3′-(1,2-dipalmitoyl-sn-glycero-3-phosphate) diC₁₆- 3′-dT

Other Notes

Catalyst used in the phosphite triester method of oligonucleotide synthesis for the coupling of (dialkylamino)phosphines

Disclaimer

Saturated solution at room temperature; storage below room temperature causes precipitation.

pictograms

GHS02,GHS07

signalword

Danger

hcodes

H225,H302 + H312 + H332,H319

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

41.0 °F - closed cup

flash_point_c

5 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Azidoazomethine-tetrazole isomerism in solution: A thermochemical study.

Cubero E, et al.

The Journal of Organic Chemistry, 63(7), 2354-2356 (1998)

Anionic nucleotide--lipids for in vitro DNA transfection.

Salim Khiati et al.

Bioconjugate chemistry, 20(9), 1765-1772 (2009-08-29)

A family of new anionic nucleotide based lipids featuring thymidine-3'-monophosphate as nucleotide and 1,2-diacyl-sn-glycerol as lipid moiety for in vitro delivery of nucleic acids is described. The nucleotide lipids were prepared in three steps starting from 1,2-diacyl-sn-glycerols and 2'-deoxythymidine-3'-phosphoramidite. Gel

Highly efficient DNA compaction mediated by an in vivo antitumor-active tetrazolato-bridged dinuclear platinum(II) complex.

Yuko Yoshikawa et al.

Inorganic chemistry, 50(22), 11729-11735 (2011-10-19)

We investigated the effects of antitumor-active tetrazolato-bridged dinuclear platinum(II) complexes [{cis-Pt(NH(3))(2)}(2)(μ-OH)(μ-tetrazolato-N(1),N(2))](2+) (1) and [{cis-Pt(NH(3))(2)}(2)(μ-OH)(μ-tetrazolato-N(2),N(3))](2+) (2) on the higher-order structure of a large DNA molecule (T4 phage DNA, 166 kbp) in aqueous solution through single-molecule observation by fluorescence microscopy. Complexes 1

Synthesis and biological evaluation of new N-acyl-homoserine-lactone analogues, based on triazole and tetrazole scaffolds, acting as LuxR-dependent quorum sensing modulators.

Mohamad Sabbah et al.

Bioorganic & medicinal chemistry, 20(15), 4727-4736 (2012-07-04)

New analogues of N-acyl-homoserine-lactone (AHL), in which the amide was replaced by a triazole or tetrazole ring, were prepared and tested for their activity as LuxR-dependent QS modulators. Several compounds showed a level of antagonistic or agonistic activity, notably some

Rapid, photoactivatable turn-on fluorescent probes based on an intramolecular photoclick reaction.

Zhipeng Yu et al.

Journal of the American Chemical Society, 133(31), 11912-11915 (2011-07-09)

Photoactivatable fluorescent probes are invaluable tools for the study of biological processes with high resolution in space and time. Numerous strategies have been developed in generating photoactivatable fluorescent probes, most of which rely on the photo-"uncaging" and photoisomerization reactions. To

View All Related Papers

Global Trade Item Number

SKU	GTIN
88185-500ML	04061838121035
88185-100ML	04061833062067

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service