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89270

Thymidine

Name: Thymidine
Brand: SIGMA

≥99.0% (HPLC), synthetic, powder

Synonym(s):

1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil, 1-(2-Deoxy-β-D-ribofuranosyl)thymine, 2′-Deoxythymidine, Thymine deoxyriboside, dT

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₂O₅

CAS Number:

50-89-5

Molecular Weight:

242.23

NACRES:

NA.51

PubChem Substance ID:

329769717

UNSPSC Code:

41106305

EC Number:

200-070-4

MDL number:

MFCD00006537

Beilstein/REAXYS Number:

89285

Assay:

≥99.0% (HPLC)

Biological source:

synthetic

Form:

powder

Solubility:

hot water: 1 g/10 mL

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Product Name

Thymidine, ≥99.0% (HPLC)

biological source

synthetic

Quality Level

200

assay

≥99.0% (HPLC)

form

powder

optical activity

[α]20/D +19±1°, c = 1% in H₂O

mp

185-190 °C, 186-188 °C (lit.)

solubility

hot water: 1 g/10 mL

SMILES string

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

InChI key

IQFYYKKMVGJFEH-XLPZGREQSA-N

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Related Categories

Biochemicals

Nucleosides and Nucleotides

Chemistry & Biochemicals

Application

Thymidine has been used:

to culture human fibroblast cell lines.
in in vitro wound healing assay.
to culture various cancer cell lines.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Telbivudine improves renal function in patients with chronic hepatitis B.

Edward J Gane et al.

Gastroenterology, 146(1), 138-146 (2013-09-27)

There is a close relationship between chronic hepatitis B virus infection and chronic renal disease. We analyzed changes in renal function using different markers of glomerular filtration rate (GFR) in multiple studies of telbivudine treatment of patients with chronic hepatitis

The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients.

Anne P Bouvy et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(8), 1587-1597 (2014-04-29)

To evaluate the influence of induction therapy on Tregs we investigated their origin, kinetics and function in kidney transplant patients after treatment with T-cell depleting rabbit antithymocyte globulin (rATG) or IL-2 receptor antagonist basiliximab. Flow cytometry was used to study

Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.

Michael V Airola et al.

PloS one, 9(8), e105830-e105830 (2014-08-22)

Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine. ASMase deficiency is the underlying cause of the genetic diseases Niemann-Pick Type A and B and has been implicated

In vitro and in vivo evaluation of an innocuous drug cocktail to improve the quality of folic acid targeted nuclear imaging in preclinical research.

Cristina Müller et al.

Molecular pharmaceutics, 10(3), 967-974 (2013-02-12)

Folate receptor (FR) targeting is an attractive strategy for nuclear imaging of cancer and activated macrophages through application of folic acid radioconjugates. However, significant renal accumulation of folate radioconjugates and hence exceedingly high emission of radiation from the kidneys may

Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.

Yee Suan Poo et al.

PLoS neglected tropical diseases, 8(12), e3354-e3354 (2014-12-05)

The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has prompted a quest to understand the correlates of protection against virus and disease in order to inform development of new interventions. Herein we highlight the propensity of CHIKV infections

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Global Trade Item Number

SKU	GTIN
89270-1G	04061833075685
89270-25G	04061833416082
89270-5G	04061833075692

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